Retinoid signaling can repress blastula Wnt signaling and impair dorsal development in Xenopus embryo
文献类型：期刊论文
| 作者 | Li, Shuangwei2,3; Lou, Xin2,3; Wang, Jinhu1,2,3; Liu, Bin2,3; Ma, Lanping4 ; Su, Zhepeng4; Ding, Xiaoyan3
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| 刊名 | DIFFERENTIATION
 |
| 出版日期 | 2008-10 |
| 卷号 | 76期号:8页码:897-907 |
| ISSN号 | 0301-4681 |
| 关键词 | retinoids retinoic acid Wnt signaling beta-catenin Xenopus dorsal development |
| DOI | 10.1111/j.1432-0436.2008.00269.x |
| 文献子类 | Article |
| 英文摘要 | Vitamin A derivatives (retinoids) are actively involved during vertebrate embryogenesis. However, exogenous retinoids have also long been known as potent teratogens. The defects caused by retinoid treatment are complex. Here, we provided evidence that RAR-mediated retinoid signaling can repress Xenopus blastula Wnt signaling and impair dorsal development. Exogenous retinoic acid (RA) could antagonize the dorsalizing effects of lithium chloride-mediated Wnt activation in blastula embryos. The Wnt-responsive reporter gene transgenesis and luciferase assay showed that excess RA can repress the Wnt signaling in blastula embryos. In addition, the downstream target genes of the Wnt signaling that direct embryonic dorsal development, were also down-regulated in the RA-treated embryos. Mechanically, RA did not interfere with the stability of beta-catenin, but promoted its nuclear accumulation. The inverse agonist of retinoic acid receptors (RAR) rescued the Wnt signaling repression by RA and relieved the RA-induced nuclear accumulation of beta-catenin. Our results explain one of the reasons for the complicated teratogenic effects of retinoids and shed light on the endogenous way of interactions between two developmentally important signaling pathways. |
| WOS关键词 | NODAL-RELATED GENES ; BETA-CATENIN ; CORTICAL ROTATION ; ACID RECEPTOR ; AXIS SPECIFICATION ; NUCLEAR RECEPTORS ; NEURAL INDUCTION ; MOLECULAR-MECHANISM ; SPEMANNS ORGANIZER ; ACTIVE REPRESSION |
| 资助项目 | National Natural Science Foundation of China[90408005] ; National Natural Science Foundation of China[30270650] ; National Key Project for Basic Science Research of China[2005CB522704] ; National Key Project for Basic Science Research of China[2007CB947900] |
| WOS研究方向 | Cell Biology ; Developmental Biology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000259360300006 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272791]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Ding, Xiaoyan |
| 作者单位 | 1.Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA; 2.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Biochem & Cell Biol, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Meteria Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Shuangwei,Lou, Xin,Wang, Jinhu,et al. Retinoid signaling can repress blastula Wnt signaling and impair dorsal development in Xenopus embryo[J]. DIFFERENTIATION,2008,76(8):897-907. |
| APA | Li, Shuangwei.,Lou, Xin.,Wang, Jinhu.,Liu, Bin.,Ma, Lanping.,...&Ding, Xiaoyan.(2008).Retinoid signaling can repress blastula Wnt signaling and impair dorsal development in Xenopus embryo.DIFFERENTIATION,76(8),897-907. |
| MLA | Li, Shuangwei,et al."Retinoid signaling can repress blastula Wnt signaling and impair dorsal development in Xenopus embryo".DIFFERENTIATION 76.8(2008):897-907. |
入库方式： OAI收割
来源：上海药物研究所
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