Three-component, one-pot synthesis of novel 2,4-substituted 5-azolylthiopyrimidine library for screening against anti-influenza virus A
文献类型：期刊论文
| 作者 | Cheng, Gang; Li, Shukun; Li, Jingya ; Hu, Youhong
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2008-02-01 |
| 卷号 | 18期号:3页码:1177-1180 |
| 关键词 | one-pot synthesis Michael-addition condensation 5-azolylthiopyridines heterocycle libraries anti-influenza |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2007.11.117 |
| 文献子类 | Article |
| 英文摘要 | A novel one-pot synthesis of 2,4-substituted 5-azolylthiopyrimidines is achieved by sequential Michael-addition of 3-iodochromones with mercaptoazole (or mercaptotriazoles) and then condensation with a variety of amidines. Compound A(1)B(6)C(1) exhibits a potent anti-influenza virus A activity with an IC50 value of 21.56 mg/mL and SI value of 9. (C) 2007 Elsevier Ltd. All rights reserved. |
| WOS关键词 | DERIVATIVES ; PYRIMIDINES ; INHIBITORS ; AMIDINES |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000253720400060 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272986]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Hu, Youhong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Gang,Li, Shukun,Li, Jingya,et al. Three-component, one-pot synthesis of novel 2,4-substituted 5-azolylthiopyrimidine library for screening against anti-influenza virus A[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2008,18(3):1177-1180. |
| APA | Cheng, Gang,Li, Shukun,Li, Jingya,&Hu, Youhong.(2008).Three-component, one-pot synthesis of novel 2,4-substituted 5-azolylthiopyrimidine library for screening against anti-influenza virus A.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,18(3),1177-1180. |
| MLA | Cheng, Gang,et al."Three-component, one-pot synthesis of novel 2,4-substituted 5-azolylthiopyrimidine library for screening against anti-influenza virus A".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18.3(2008):1177-1180. |
入库方式： OAI收割
来源：上海药物研究所
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