Easily accessible C-2-symmetric chiral bicyclo[3.3.0] dienes as ligands for rhodium-catalyzed asymmetric 1,4-addition
文献类型：期刊论文
| 作者 | Feng, Chen-Guo1; Wang, Zhi-Qian1; Tian, Ping1; Xu, Ming-Hua1,2 ; Lin, Guo-Qiang1
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| 刊名 | CHEMISTRY-AN ASIAN JOURNAL
 |
| 出版日期 | 2008 |
| 卷号 | 3期号:8-9页码:1511-1516 |
| 关键词 | 1,4-addition asymmetric catalysis boronic acids diene ligands rhodium |
| ISSN号 | 1861-4728 |
| DOI | 10.1002/asia.200800049 |
| 文献子类 | Article |
| 英文摘要 | The synthesis of a new type of C-2-symmetric chiral diene ligands with a nonbridged bicyclic [3.3.0] backbone was successfully introduced. Using highly efficient lipase-catalyzed transesterification and Suzuki-coupling strategies, a broad family of enantiopure 3,6-disubstituted bicyclo[3.3.0] dienes with different electronic and steric properties could be easily prepared. The application of these new diene ligands in the Rh-catalyzed asymmetric 1,4-addition of arylboronic acids to alpha,beta-unsaturated carbonyl compounds have been examined, and excellent enantioselectivities (up to 98% ee) as well as good yields are achieved under very mild reaction conditions at room temperature. |
| WOS关键词 | ELECTRON-DEFICIENT OLEFINS ; ARYLBORONIC ACIDS ; N-TOSYLARYLIMINES ; HIGH-PERFORMANCE ; ALPHA,BETA-UNSATURATED KETONES ; ARYLATIVE CYCLIZATION ; CONJUGATE ADDITIONS ; KINETIC RESOLUTION ; STEERING LIGANDS ; COMPLEX |
| 资助项目 | National Natural Science Foundation of China[20632060] ; National Natural Science Foundation of China[20721003] ; Shanghai Institute of Materia Medica[00000000] ; Chinese Academy of Sciences[00000000] ; Major State Basic Research Development Program[2006CB806106] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000259119400036 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273012]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Xu, Ming-Hua |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Chen-Guo,Wang, Zhi-Qian,Tian, Ping,et al. Easily accessible C-2-symmetric chiral bicyclo[3.3.0] dienes as ligands for rhodium-catalyzed asymmetric 1,4-addition[J]. CHEMISTRY-AN ASIAN JOURNAL,2008,3(8-9):1511-1516. |
| APA | Feng, Chen-Guo,Wang, Zhi-Qian,Tian, Ping,Xu, Ming-Hua,&Lin, Guo-Qiang.(2008).Easily accessible C-2-symmetric chiral bicyclo[3.3.0] dienes as ligands for rhodium-catalyzed asymmetric 1,4-addition.CHEMISTRY-AN ASIAN JOURNAL,3(8-9),1511-1516. |
| MLA | Feng, Chen-Guo,et al."Easily accessible C-2-symmetric chiral bicyclo[3.3.0] dienes as ligands for rhodium-catalyzed asymmetric 1,4-addition".CHEMISTRY-AN ASIAN JOURNAL 3.8-9(2008):1511-1516. |
入库方式： OAI收割
来源：上海药物研究所
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