Synthesis and pharmacological evaluation of 6,7-indolo/thiazolo-morphinans - Further SAR of levorphanol
文献类型：期刊论文
| 作者 | Zhang, Ao ; Li, Fuying; Ding, Chunyong; Yao, Qizhen; Knapp, Brian I.; Bidlack, Jean M.; Neumeyer, John L.
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| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2007-05-31 |
| 卷号 | 50期号:11页码:2747-2751 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/jm0701674 |
| 文献子类 | Article |
| 英文摘要 | To further extend the structure-activity relationships of levorphanol, two series of novel morphinans were prepared by incorporation of an indole or aminothiazole fragment to the hexyl ring (ring C) in levorphanol. Such morphinans differed from previously reported ligands in that such indole- or aminothiazole-containing morphinans displayed enhanced binding affinity to the delta opioid receptor, while the affinity to kappa and mu receptors was slightly reduced. |
| WOS关键词 | 4-HYDROXYL GROUP ; OPIOID RECEPTORS ; ELIMINATION ; MORPHINE ; DERIVATIVES ; ANALOGS ; DIHYDROTHEBAINONE ; ANTAGONISTS ; AFFINITY ; LIGANDS |
| 资助项目 | NIDA NIH HHS[R01-DA14251] ; NIDA NIH HHS[K05-DA 00360] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000246694500028 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273253]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Zhang, Ao |
| 作者单位 | 1.Univ Rochester, Sch Med & Dent, Dept Pharmacol & Physiol, Rochester, NY 14642 USA 2.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China 3.Harvard Univ, McLean Hosp, Sch Med, Med Chem Lab, Belmont, MA 02478 USA 4.Chinese Acad Sci, Shanghai Inst Mat Med, Bioorgan & Med Chem Lab, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ao,Li, Fuying,Ding, Chunyong,et al. Synthesis and pharmacological evaluation of 6,7-indolo/thiazolo-morphinans - Further SAR of levorphanol[J]. JOURNAL OF MEDICINAL CHEMISTRY,2007,50(11):2747-2751. |
| APA | Zhang, Ao.,Li, Fuying.,Ding, Chunyong.,Yao, Qizhen.,Knapp, Brian I..,...&Neumeyer, John L..(2007).Synthesis and pharmacological evaluation of 6,7-indolo/thiazolo-morphinans - Further SAR of levorphanol.JOURNAL OF MEDICINAL CHEMISTRY,50(11),2747-2751. |
| MLA | Zhang, Ao,et al."Synthesis and pharmacological evaluation of 6,7-indolo/thiazolo-morphinans - Further SAR of levorphanol".JOURNAL OF MEDICINAL CHEMISTRY 50.11(2007):2747-2751. |
入库方式： OAI收割
来源：上海药物研究所
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