Characterization of related impurities in megestrol acetate
文献类型：期刊论文
| 作者 | Guo, FJ; Feng, HJ ; Wang, YF; Zhang, C; Li, YC
|
| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| 出版日期 | 2006-06-16 |
| 卷号 | 41期号:4页码:1418-1422 |
| 关键词 | megestrol acetate related impurities structural elucidation |
| ISSN号 | 0731-7085 |
| DOI | 10.1016/j.jpba.2006.02.048 |
| 文献子类 | Article |
| 英文摘要 | Three new compounds, 17 alpha-acetoxy-2,6-dimethylpregna-1,4,6-triene-3,20-dione (1), 17 alpha-acetoxy-2 alpha,6-dimethylpregna-4,6-diene-3,20-dione (2), 17 alpha-acetoxy-6 alpha-methoxylmethylpregna-4-ene-3,20-dione (3), together with five known ones, 17 alpha-acetoxy-6 beta-hydroxyl-6 alpha-methylpregna-4-ene-3,20-dione (4), 17 alpha-acetoxy-6 alpha-hydroxyl-6 beta-methylpregna-4-ene-3,20-dione (5), 17 alpha-acetoxy-pregna-4-ene-3,6,20-trione (6), 17 alpha-acetoxy-pregna-4-ene-3,20-dione (7) and 17 alpha-acetoxy-6-methylene-pregna-4-ene-3,20-dione (8), were isolated and identified from the residual mother liquor of megestrol acetate. Their structures were established by spectroscopic methods. These compounds seem to be minor impurities in production of the drug megestrol acetate. (c) 2006 Elsevier B.V. All rights reserved. |
| WOS关键词 | DERIVATIVES |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000238491100051 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273566]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Li, YC |
| 作者单位 | 1.Shenzhou Pharm Inc, Xianju 317300, Zhejiang, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, FJ,Feng, HJ,Wang, YF,et al. Characterization of related impurities in megestrol acetate[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2006,41(4):1418-1422. |
| APA | Guo, FJ,Feng, HJ,Wang, YF,Zhang, C,&Li, YC.(2006).Characterization of related impurities in megestrol acetate.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,41(4),1418-1422. |
| MLA | Guo, FJ,et al."Characterization of related impurities in megestrol acetate".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 41.4(2006):1418-1422. |
入库方式： OAI收割
来源：上海药物研究所
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