Recent advances towards the discovery of dopamine receptor ligands
文献类型：期刊论文
| 作者 | Zhang, Ao ; Kan, Ying; Li, Fuying
|
| 刊名 | EXPERT OPINION ON THERAPEUTIC PATENTS
 |
| 出版日期 | 2006-05 |
| 卷号 | 16期号:5页码:587-630 |
| 关键词 | atypical antipsychotic brain disorder CNS dopamine dopamine agonist dopamine antagonist dopamine receptor Parkinson's disease schizophrenia serotonin |
| ISSN号 | 1354-3776 |
| DOI | 10.1517/13543776.16.5.587 |
| 文献子类 | Review |
| 英文摘要 | Dopamine is a key regulator in the CNS, contributing importantly to functions of arousal and attention, initiation of movement, perception, motivation and emotion. its imbalance has been implicated in the pathophysiology, and more clearly in the pharmacology, of a number of neurobehavioural disorders, including Parkinson's disease, schizophrenia, mania and depression, alcohol and drug abuse, as well as attention and eating disorders. Five major dopamine receptor subtypes (D1 - D5) have been identified, with distinct differences in their genes and peptide composition, molecular functions and neuropharmacology. These receptors represent the rational targets for the treatment of a large number of neurological and psychiatric disorders. In recent years, substantial efforts have addressed the most recently described dopamine receptor types, particularly types D3, D4 and D5, although most research involves the longer-known D1 and D2 dopamine receptors. Current pharmacological efforts in medicinal chemistry and neuropharmacology include the development of D1 full agonists and D2 partial agonists, as well as agents with dopaminergic activity combined with effects at CNS serotonergic, muscarinic, adrenergic and histaminic receptors. This review provides an overview of the recent patent literature during 2003 - 2005 on the development of therapeutic agents, mainly targeting the five dopamine receptors. |
| WOS关键词 | ATYPICAL ANTIPSYCHOTIC AGENTS ; GAMMA-S BINDING ; PARKINSONS-DISEASE ; DRUG-TREATMENT ; WEIGHT-GAIN ; HUMAN-BRAIN ; SCHIZOPHRENIA ; AGONIST ; DERIVATIVES ; ANTAGONISTS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000237502300003 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273606]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Zhang, Ao |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Synthet Organ & Med Chem Lab, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ao,Kan, Ying,Li, Fuying. Recent advances towards the discovery of dopamine receptor ligands[J]. EXPERT OPINION ON THERAPEUTIC PATENTS,2006,16(5):587-630. |
| APA | Zhang, Ao,Kan, Ying,&Li, Fuying.(2006).Recent advances towards the discovery of dopamine receptor ligands.EXPERT OPINION ON THERAPEUTIC PATENTS,16(5),587-630. |
| MLA | Zhang, Ao,et al."Recent advances towards the discovery of dopamine receptor ligands".EXPERT OPINION ON THERAPEUTIC PATENTS 16.5(2006):587-630. |
入库方式： OAI收割
来源：上海药物研究所
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