中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 药物化学研究室
Isolation and identification of novel impurities in spironolactone

文献类型：期刊论文

作者Chen, H; Wang, YF; Yang, ZD; Li, YC
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
出版日期2006-03-18
卷号40期号:5页码:1263-1267
关键词steroids spironolactone chromatographic methods spectrometric analysis
ISSN号0731-7085
DOI10.1016/j.jpba.2005.09.003
文献子类Article
英文摘要Three known and five new steroidal compounds as impurities in spironolactone were isolated from the enriched mother liquor by using various chromatographic methods. Their structures were elucidated by spectrometric analysis. New compounds were characterized as 3-(3,3-dimethoxy-5 alpha,7 alpha-epidithio-17 beta-hydroxy-4-androstan-17 alpha-yl) propionic acid gamma-lactone (6); 3-(3-oxo-7 alpha-acetylthio-6 beta,17 beta-dihydroxy-4-androsten-17 alpha-yl) propionic acid gamma-lactone (7); 7 alpha-acetylthio-17 beta-20-isopropylidendioxy-21-nor-17 alpha-pregn-4-en-3-one (8); 7 alpha-acetylthio-3-oxo-pregna-4,17(20)i-dien-22-oic acid methyl ester (9) and 7 alpha-acetylthio-17-methyl-18-nor-androsta-4-en-3-one (10). (c) 2005 Elsevier B.V. All rights reserved.
WOS关键词NUCLEAR MAGNETIC-RESONANCE ; PLASMA-RENIN ACTIVITY ; HYPERTENSION
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000236234900032
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/273642]  
专题药物化学研究室
通讯作者Li, YC
作者单位1.Zhejiang Xianju Zhiyao Erchang, Zhejiang 317300, Peoples R China
2.Chinese Acad Sci, Grad Sch, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
3.Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Hebei, Peoples R China
推荐引用方式
GB/T 7714		 Chen, H,Wang, YF,Yang, ZD,et al. Isolation and identification of novel impurities in spironolactone[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2006,40(5):1263-1267.
APA Chen, H,Wang, YF,Yang, ZD,&Li, YC.(2006).Isolation and identification of novel impurities in spironolactone.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,40(5),1263-1267.
MLA Chen, H,et al."Isolation and identification of novel impurities in spironolactone".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 40.5(2006):1263-1267.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。