Isolation and identification of novel impurities in spironolactone
文献类型:期刊论文
作者 | Chen, H; Wang, YF; Yang, ZD; Li, YC |
刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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出版日期 | 2006-03-18 |
卷号 | 40期号:5页码:1263-1267 |
关键词 | steroids spironolactone chromatographic methods spectrometric analysis |
ISSN号 | 0731-7085 |
DOI | 10.1016/j.jpba.2005.09.003 |
文献子类 | Article |
英文摘要 | Three known and five new steroidal compounds as impurities in spironolactone were isolated from the enriched mother liquor by using various chromatographic methods. Their structures were elucidated by spectrometric analysis. New compounds were characterized as 3-(3,3-dimethoxy-5 alpha,7 alpha-epidithio-17 beta-hydroxy-4-androstan-17 alpha-yl) propionic acid gamma-lactone (6); 3-(3-oxo-7 alpha-acetylthio-6 beta,17 beta-dihydroxy-4-androsten-17 alpha-yl) propionic acid gamma-lactone (7); 7 alpha-acetylthio-17 beta-20-isopropylidendioxy-21-nor-17 alpha-pregn-4-en-3-one (8); 7 alpha-acetylthio-3-oxo-pregna-4,17(20)i-dien-22-oic acid methyl ester (9) and 7 alpha-acetylthio-17-methyl-18-nor-androsta-4-en-3-one (10). (c) 2005 Elsevier B.V. All rights reserved. |
WOS关键词 | NUCLEAR MAGNETIC-RESONANCE ; PLASMA-RENIN ACTIVITY ; HYPERTENSION |
WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
语种 | 英语 |
WOS记录号 | WOS:000236234900032 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
源URL | [http://119.78.100.183/handle/2S10ELR8/273642] ![]() |
专题 | 药物化学研究室 |
通讯作者 | Li, YC |
作者单位 | 1.Zhejiang Xianju Zhiyao Erchang, Zhejiang 317300, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 3.Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Hebei, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, H,Wang, YF,Yang, ZD,et al. Isolation and identification of novel impurities in spironolactone[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2006,40(5):1263-1267. |
APA | Chen, H,Wang, YF,Yang, ZD,&Li, YC.(2006).Isolation and identification of novel impurities in spironolactone.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,40(5),1263-1267. |
MLA | Chen, H,et al."Isolation and identification of novel impurities in spironolactone".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 40.5(2006):1263-1267. |
入库方式: OAI收割
来源:上海药物研究所
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