Design and synthesis of pyrido[1,2-e]purin-4(3H)-one derivatives as potential PDE 5 inhibitors
文献类型：期刊论文
| 作者 | Xia, GX; Li, JF ; Lai, SA; Peng, AM; Zhang, SJ; Wei, XH; Chen, XJ; Shen, JS; Ji, RY
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| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2005-10 |
| 卷号 | 16期号:10页码:1283-1286 |
| 关键词 | pyrido[1,2-e]purin-4(3H)-one PDE5 inhibitor sildenafil erectile dysfunction (ED) |
| ISSN号 | 1001-8417 |
| 文献子类 | Article |
| 英文摘要 | A novel series of pyrido[1,2-e]purin-4(3H)-one derivatives containing polar substituents on 5 '-position were designed and prepared as potential PDE5 inhibitors. This paper reports the synthetic routes, H-1-NMR data, and the PDE5 inhibitory activities of the target compounds. The polar piperazinyl group contained (on 5 '-position) compound, 3B2, showed the highest activity among the tested derivatives but less potency than sildenafil 1. |
| WOS关键词 | ERECTILE DYSFUNCTION ; PHOSPHODIESTERASE |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000232638500002 |
| 出版者 | CHINESE CHEMICAL SOCIETY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273797]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Shen, JS |
| 作者单位 | 1.Topharman Shanghai Co Ltd, Shanghai 201209, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, GX,Li, JF,Lai, SA,et al. Design and synthesis of pyrido[1,2-e]purin-4(3H)-one derivatives as potential PDE 5 inhibitors[J]. CHINESE CHEMICAL LETTERS,2005,16(10):1283-1286. |
| APA | Xia, GX.,Li, JF.,Lai, SA.,Peng, AM.,Zhang, SJ.,...&Ji, RY.(2005).Design and synthesis of pyrido[1,2-e]purin-4(3H)-one derivatives as potential PDE 5 inhibitors.CHINESE CHEMICAL LETTERS,16(10),1283-1286. |
| MLA | Xia, GX,et al."Design and synthesis of pyrido[1,2-e]purin-4(3H)-one derivatives as potential PDE 5 inhibitors".CHINESE CHEMICAL LETTERS 16.10(2005):1283-1286. |
入库方式： OAI收割
来源：上海药物研究所
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