Structural features of an immunoactive acidic arabinogalactan from Centella asiatica
文献类型：期刊论文
| 作者 | Wang, XS; Zheng, Y; Zuo, JP ; Fang, JN
|
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2005-02-18 |
| 卷号 | 59期号:3页码:281-288 |
| 关键词 | Centella asiatica immunological activity polysaccharide arabinogalactan pectolyase modification |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2004.07.005 |
| 文献子类 | Article |
| 英文摘要 | A water-soluble acidic arabinogalactan, named HBN with a molecular mass of 5.4 x 10(5) Da determined by HPGPC, was obtained from Centella asiatica. HBN contained Ara, Gal, Rha, GalA and Xyl in molar ratios of 1.0:1.9:0.26:0.30:0.15. The acetyl content was estimated to be 2.5%. Using methylation analysis, partial acid hydrolysis, NalO(4) oxidation-Smith degradation, RI, NMR, ESI-MS, HPGPC, pectolyase-treatment methods, the structure of HBN was elucidated. HBN had a core composed of Rha and GalA, with arabinogalactosyl and xylosyl chains were attached to this core. Seventy-six percent Ara residues were located at termini and linked to O-6 of Gal residues. HBN had remarkable immunoenhancing activities on T- and B-lymphocytes in vitro and vivo tests. It increased spleen index and inhibited the level of IgG. With the stimulation of SAC, it enhanced the secretion of IFN-gamma, IL-12 and IL-6, and inhibited IL-10. Its derivatives by NalO(4) oxidation-Smith degradation and enzyme-treatment possessed immunological activities in vitro. (C) 2004 Elsevier Ltd. All rights reserved. |
| WOS关键词 | IMMUNOLOGICAL ACTIVITY ; POLYSACCHARIDES ; PROTEINS ; ROOTS ; MONOSACCHARIDES ; PECTIN ; FORM |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000227166200002 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273907]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Fang, JN |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, XS,Zheng, Y,Zuo, JP,et al. Structural features of an immunoactive acidic arabinogalactan from Centella asiatica[J]. CARBOHYDRATE POLYMERS,2005,59(3):281-288. |
| APA | Wang, XS,Zheng, Y,Zuo, JP,&Fang, JN.(2005).Structural features of an immunoactive acidic arabinogalactan from Centella asiatica.CARBOHYDRATE POLYMERS,59(3),281-288. |
| MLA | Wang, XS,et al."Structural features of an immunoactive acidic arabinogalactan from Centella asiatica".CARBOHYDRATE POLYMERS 59.3(2005):281-288. |
入库方式： OAI收割
来源：上海药物研究所
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