Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease
文献类型：期刊论文
| 作者 | Shao, D; Zou, CY; Luo, C ; Tang, XC; Li, YC
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2004-09-20 |
| 卷号 | 14期号:18页码:4639-4642 |
| 关键词 | tacrine-E2020 hybrids acetylcholinesterase inhibitor Alzheimer's disease |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2004.07.005 |
| 文献子类 | Article |
| 英文摘要 | Tacrine-E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's disease were assayed. The optimum hybrid inhibitor 3 is 37-fold more potent and 31-fold more selective than tacrine in vitro. (C) 2004 Elsevier Ltd. All rights reserved. |
| WOS关键词 | HIGHLY POTENT ; HUPERZINE ; ACETYLCHOLINESTERASE/BUTYRYLCHOLINESTERASE ; ANALOGS |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000223709400007 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274020]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Li, YC |
| 作者单位 | Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shao, D,Zou, CY,Luo, C,et al. Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2004,14(18):4639-4642. |
| APA | Shao, D,Zou, CY,Luo, C,Tang, XC,&Li, YC.(2004).Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,14(18),4639-4642. |
| MLA | Shao, D,et al."Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14.18(2004):4639-4642. |
入库方式： OAI收割
来源：上海药物研究所
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