中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Structural characterization and biological activities of SC4, an acidic polysaccharide from Salvia chinensis

文献类型:期刊论文

作者Liu, CP; Fang, JN; Li, XY; Xiao, XQ
刊名ACTA PHARMACOLOGICA SINICA
出版日期2002-02
卷号23期号:2页码:162-166
关键词Salvia chinensis polysaccharides molecular structure T-lymphocytes B-lymphocytes PC12 cells biomolecular nuclear magnetic resonance
ISSN号1671-4083
文献子类Article
英文摘要AIM: To study the chemical characterization and some biological activities of an acidic polysaccharide, named SC4 from Salvia chinensis. METHODS: Chemical and spectral methods were employed to identify the structural characterization of SC4. Effect of SC4 on the proliferation of T- and B-lymphocytes both in vivo and in vitro was measured at various concentrations, and the protective effects of SC4 on PC12 cells against H2O2 induced injury was observed. RESULTS: SC4 was a highly branched polysaccharide with mean molecular weight of 4.5 x 10(5), composed of Rha, Xyl, Ser, Gal, and GalA in the molar ratio of 1.0: 7.0: 5.3: 1.2: 4.2. Methylation analysis and NMR identified the linkages of the residues of SC4. SC4 increased the B-lymphocyte proliferation and spleen weight remarkably while no obvious changes were examined in T-lymphocyte proliferation, thymus weight, and the level of IgG and C3 in blood of mice. Moreover, SC4 enhanced the PC12 cells viability after H2O2 treatment. CONCLUSION: SC4, the acidic polysaccharide with complicated structure, was a B-lymphocyte stimulator and protected PC12 cells at the concentration of 20 mg/L against H2O2 induced injury.
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
CSCD记录号CSCD:1366724
WOS记录号WOS:000173710300013
出版者ACTA PHARMACOLOGICA SINICA
源URL[http://119.78.100.183/handle/2S10ELR8/274390]  
专题药理学第三研究室
通讯作者Fang, JN
作者单位Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714
Liu, CP,Fang, JN,Li, XY,et al. Structural characterization and biological activities of SC4, an acidic polysaccharide from Salvia chinensis[J]. ACTA PHARMACOLOGICA SINICA,2002,23(2):162-166.
APA Liu, CP,Fang, JN,Li, XY,&Xiao, XQ.(2002).Structural characterization and biological activities of SC4, an acidic polysaccharide from Salvia chinensis.ACTA PHARMACOLOGICA SINICA,23(2),162-166.
MLA Liu, CP,et al."Structural characterization and biological activities of SC4, an acidic polysaccharide from Salvia chinensis".ACTA PHARMACOLOGICA SINICA 23.2(2002):162-166.

入库方式: OAI收割

来源:上海药物研究所

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