Structural characterization and biological activities of SC4, an acidic polysaccharide from Salvia chinensis
文献类型：期刊论文
| 作者 | Liu, CP; Fang, JN; Li, XY; Xiao, XQ |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2002-02 |
| 卷号 | 23期号:2页码:162-166 |
| 关键词 | Salvia chinensis polysaccharides molecular structure T-lymphocytes B-lymphocytes PC12 cells biomolecular nuclear magnetic resonance |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the chemical characterization and some biological activities of an acidic polysaccharide, named SC4 from Salvia chinensis. METHODS: Chemical and spectral methods were employed to identify the structural characterization of SC4. Effect of SC4 on the proliferation of T- and B-lymphocytes both in vivo and in vitro was measured at various concentrations, and the protective effects of SC4 on PC12 cells against H2O2 induced injury was observed. RESULTS: SC4 was a highly branched polysaccharide with mean molecular weight of 4.5 x 10(5), composed of Rha, Xyl, Ser, Gal, and GalA in the molar ratio of 1.0: 7.0: 5.3: 1.2: 4.2. Methylation analysis and NMR identified the linkages of the residues of SC4. SC4 increased the B-lymphocyte proliferation and spleen weight remarkably while no obvious changes were examined in T-lymphocyte proliferation, thymus weight, and the level of IgG and C3 in blood of mice. Moreover, SC4 enhanced the PC12 cells viability after H2O2 treatment. CONCLUSION: SC4, the acidic polysaccharide with complicated structure, was a B-lymphocyte stimulator and protected PC12 cells at the concentration of 20 mg/L against H2O2 induced injury. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:1366724 |
| WOS记录号 | WOS:000173710300013 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274390]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Fang, JN |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, CP,Fang, JN,Li, XY,et al. Structural characterization and biological activities of SC4, an acidic polysaccharide from Salvia chinensis[J]. ACTA PHARMACOLOGICA SINICA,2002,23(2):162-166. |
| APA | Liu, CP,Fang, JN,Li, XY,&Xiao, XQ.(2002).Structural characterization and biological activities of SC4, an acidic polysaccharide from Salvia chinensis.ACTA PHARMACOLOGICA SINICA,23(2),162-166. |
| MLA | Liu, CP,et al."Structural characterization and biological activities of SC4, an acidic polysaccharide from Salvia chinensis".ACTA PHARMACOLOGICA SINICA 23.2(2002):162-166. |
入库方式： OAI收割
来源：上海药物研究所
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