中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 药物化学研究室
Synthesis of Hexahydro-1H-1,4-diazepine analogues carrying the segment of (1-arylacetamide-2-tertiaryamide) ethane (II)

文献类型：期刊论文

作者Shen, JS; Lei, LJ; Yan, TM; Wei, M; Ji, RY
刊名ACTA CHIMICA SINICA
出版日期2001
卷号59期号:8页码:1317-1322
关键词selective kappa receptor agonists hexahydro-1H-1,4-diazepine analogues (1-arylacetamide-2-tertiaryamide) ethane structure
ISSN号0567-7351
文献子类Article
英文摘要2-(1-(4-(N-phenyl-N- propionyl) amino) piperidyl)-hexahydro-1H-1,4-diazepine 7 was prepared starting from 3 through reduction, chlorination, amine substitution, and debenzylation. Seven target compounds of hexahydro-1H-1,4-diazepine analogues carrying the segment of (1- arylacetamide-2-tertiaryamide) ethane were synthesized through selective acylation and acylation of compound 7, and the four target compounds 10a similar to 10d containing hydrophilic group of hydroxy were achieved through debenzylation of 9a, 9b, 9c and 9d. These products were characterized by IR, EIMS, elementary analysis and H-1 NMR. Compounds of 9a similar to 9g and 10a similar to 10d were tested for their biological activities.
WOS关键词RECEPTOR ; POTENT ; AGONISTS
WOS研究方向Chemistry
语种中文
CSCD记录号CSCD:644199
WOS记录号WOS:000170513100027
出版者SCIENCE PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/274530]  
专题药物化学研究室
通讯作者Shen, JS
作者单位Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Shen, JS,Lei, LJ,Yan, TM,et al. Synthesis of Hexahydro-1H-1,4-diazepine analogues carrying the segment of (1-arylacetamide-2-tertiaryamide) ethane (II)[J]. ACTA CHIMICA SINICA,2001,59(8):1317-1322.
APA Shen, JS,Lei, LJ,Yan, TM,Wei, M,&Ji, RY.(2001).Synthesis of Hexahydro-1H-1,4-diazepine analogues carrying the segment of (1-arylacetamide-2-tertiaryamide) ethane (II).ACTA CHIMICA SINICA,59(8),1317-1322.
MLA Shen, JS,et al."Synthesis of Hexahydro-1H-1,4-diazepine analogues carrying the segment of (1-arylacetamide-2-tertiaryamide) ethane (II)".ACTA CHIMICA SINICA 59.8(2001):1317-1322.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。