Chemical characterization and immunological activities of an acidic polysaccharide isolated from the seeds of Cuscuta chinensis Lam
文献类型：期刊论文
| 作者 | Wang, Z ; Fang, JN; Ge, DL; Li, XY
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2000-12 |
| 卷号 | 21期号:12页码:1136-1140 |
| 关键词 | Cuscuta chinensis Lam polysaccharides nuclear magnetic resonance T-lymphocytes B-lymphocytes antibodies |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study chemical characterization and immunological activities of an acidic polysaccharide, CHC-1, isolated and purified from the seeds of Cuscuta chinensis Lam. METHODS: Both chemical and spectral methods were used to investigate the chemical characterization of CHC-1. Effect of CHC-1 on the proliferation rates of T- and B-lymphocytes both in vivo and in vitro, and antibody production in vivo was measured at various concentrations of CHC-1. RESULTS: The molecular weight of CHC-1 was estimated to be more than 1.0 x 10(6). The analytical results of sugar components indicated that CHC-1 was composed of Rha, Am, Gal, and GalA in a molar ratio of 0.8:1.0:1.5:0.3. Methylation analysis and H-1, C-13 NMR further identified the linkages of the residues of CHC-1, CHC-1 0.1 g/L promoted remarkably the proliferation of T-cells and B-cells in vitro. CHC-1 25 mg/kg, 50 mg/kg caused an evident increase in spleen weight, lymphocyte proliferation, antibody production, etc. But its effect on IgG levels was not significant. CONCLUSION: CHC-1 is a highly branched heteropolysaccharide and possessed immune enhancement activities. |
| WOS关键词 | GLYCOSIDES |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000165828500013 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274550]  |
| 专题 | 药物化学研究室 药理学第三研究室 |
| 通讯作者 | Fang, JN |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Z,Fang, JN,Ge, DL,et al. Chemical characterization and immunological activities of an acidic polysaccharide isolated from the seeds of Cuscuta chinensis Lam[J]. ACTA PHARMACOLOGICA SINICA,2000,21(12):1136-1140. |
| APA | Wang, Z,Fang, JN,Ge, DL,&Li, XY.(2000).Chemical characterization and immunological activities of an acidic polysaccharide isolated from the seeds of Cuscuta chinensis Lam.ACTA PHARMACOLOGICA SINICA,21(12),1136-1140. |
| MLA | Wang, Z,et al."Chemical characterization and immunological activities of an acidic polysaccharide isolated from the seeds of Cuscuta chinensis Lam".ACTA PHARMACOLOGICA SINICA 21.12(2000):1136-1140. |
入库方式： OAI收割
来源：上海药物研究所
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