A stereoselective synthesis of the C(3)-C(13) and C(14)-C(24) fragments of macrolactin A
文献类型：期刊论文
| 作者 | Li, SK; Xu, R; Xiao, XS; Bai, DL
|
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2000-11 |
| 卷号 | 18期号:6页码:910-923 |
| 关键词 | macrolactin A antiviral stereoselective synthesis Wittig reaction sulfone alkylation Julia olefination |
| ISSN号 | 1001-604X |
| 文献子类 | Article |
| 英文摘要 | Synthetic studies towards the C(3)-C(13) and C(14)-C(24) segments(3,4) of the potent antiviral and antitumor compound macrolactin A (1) are presented. Compound 3 Has constructed via a convergent and facile approach, exploiting Wittig olefination to generate the sensitive E,Z-diene moiety. Compound 4 was synthesized from the chiral-pool derived sulfone 39a ria an alpha -alkylation-desulfonation reaction sequence. Cu(II)-catalyzed coupling of a Grignard reagent with an allylic bromide and Julia olefination were also investigated for the preparation of compound 4. |
| WOS关键词 | ASYMMETRIC-SYNTHESIS ; ORGANOIRON METHODOLOGY ; ENANTIOMERS ; SULFOXIDES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000165702000020 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274562]  |
| 专题 | 院士及顾问专家 药物化学研究室 |
| 通讯作者 | Bai, DL |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, SK,Xu, R,Xiao, XS,et al. A stereoselective synthesis of the C(3)-C(13) and C(14)-C(24) fragments of macrolactin A[J]. CHINESE JOURNAL OF CHEMISTRY,2000,18(6):910-923. |
| APA | Li, SK,Xu, R,Xiao, XS,&Bai, DL.(2000).A stereoselective synthesis of the C(3)-C(13) and C(14)-C(24) fragments of macrolactin A.CHINESE JOURNAL OF CHEMISTRY,18(6),910-923. |
| MLA | Li, SK,et al."A stereoselective synthesis of the C(3)-C(13) and C(14)-C(24) fragments of macrolactin A".CHINESE JOURNAL OF CHEMISTRY 18.6(2000):910-923. |
入库方式： OAI收割
来源：上海药物研究所
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