Studies on the total synthesis of macrolactin A. A stereoselective synthesis of the C-3-C-13 and C-14-C-24 fragments
文献类型：期刊论文
| 作者 | Li, SK; Xu, R; Bai, DL
|
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2000-04-29 |
| 卷号 | 41期号:18页码:3463-3466 |
| 关键词 | macrolactin A antiviral stereoselective synthesis Wittig olefination sulfone alkylation |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/S0040-4039(00)00412-3 |
| 文献子类 | Article |
| 英文摘要 | Synthetic studies towards the C-3-C-13 (2) and C-14-C-24 (3) segments of the potent antiviral and antitumor compound macrolactin A (1) are presented. Segment 2 was constructed via a convergent and facile approach, exploiting Wittig olefination to generate the sensitive E,Z-diene moiety. Segment 3 was obtained from the chiral pool derived sulfone 4 via an alpha-alkylation-desulfonation reaction sequence. (C) 2000 Elsevier Science Ltd. All rights reserved. |
| WOS关键词 | ORGANOIRON METHODOLOGY |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000087060700043 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274626]  |
| 专题 | 院士及顾问专家 药物化学研究室 |
| 通讯作者 | Bai, DL |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, SK,Xu, R,Bai, DL. Studies on the total synthesis of macrolactin A. A stereoselective synthesis of the C-3-C-13 and C-14-C-24 fragments[J]. TETRAHEDRON LETTERS,2000,41(18):3463-3466. |
| APA | Li, SK,Xu, R,&Bai, DL.(2000).Studies on the total synthesis of macrolactin A. A stereoselective synthesis of the C-3-C-13 and C-14-C-24 fragments.TETRAHEDRON LETTERS,41(18),3463-3466. |
| MLA | Li, SK,et al."Studies on the total synthesis of macrolactin A. A stereoselective synthesis of the C-3-C-13 and C-14-C-24 fragments".TETRAHEDRON LETTERS 41.18(2000):3463-3466. |
入库方式： OAI收割
来源：上海药物研究所
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