A practical stereoselective synthesis of (S)-(-)-ofloxacin
文献类型：期刊论文
| 作者 | Yang, YS ; Ji, RY; Chen, KX
|
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 1999-09 |
| 卷号 | 17期号:5页码:539-544 |
| 关键词 | (S)-(-)-ofloxacin stereoselective synthesis quinolone antibacterial agent |
| ISSN号 | 1001-604X |
| 文献子类 | Article |
| 英文摘要 | A very efficient and practical procedure for preparation of(S)-( - )-ofloxacin has been developed (10 steps, overall yield greater than or equal to 45%). The key step of this approach is the regioselective nucleophilic substitution of 2-position fluorine atom of 2,3,4-tirfluoronitrobenzene by (S)-glycerol acetonide. |
| WOS关键词 | OPTICALLY-ACTIVE OFLOXACIN ; ANTIBACTERIAL ACTIVITIES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000083814600015 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274704]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Yang, YS |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, YS,Ji, RY,Chen, KX. A practical stereoselective synthesis of (S)-(-)-ofloxacin[J]. CHINESE JOURNAL OF CHEMISTRY,1999,17(5):539-544. |
| APA | Yang, YS,Ji, RY,&Chen, KX.(1999).A practical stereoselective synthesis of (S)-(-)-ofloxacin.CHINESE JOURNAL OF CHEMISTRY,17(5),539-544. |
| MLA | Yang, YS,et al."A practical stereoselective synthesis of (S)-(-)-ofloxacin".CHINESE JOURNAL OF CHEMISTRY 17.5(1999):539-544. |
入库方式： OAI收割
来源：上海药物研究所
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