Inhibitory effects of indomethacin on interleukin-1 and nitric oxide production in rat microglia in vitro
文献类型：期刊论文
| 作者 | Du, ZY; Li, XY |
| 刊名 | INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY
 |
| 出版日期 | 1999-03 |
| 卷号 | 21期号:3页码:219-225 |
| 关键词 | indomethacin interleukin-1 tumor necrosis factor-alpha nitric oxide microglia |
| ISSN号 | 0192-0561 |
| DOI | 10.1016/S0192-0561(98)00084-8 |
| 文献子类 | Article |
| 英文摘要 | Indomethacin, as a nonsteroidal antiinflammatory drug, is reported to be effective in some degree in the prevention and treatment of Alzheimer's disease (AD). Effects of indomethacin on proinflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor alpha and nitric oxide (NO) on rat microglia in vitro were investigated. The biological activities of IL-1 were assayed by thymocyte proliferation assay and the activities of TNG-alpha, by L929 cytotoxicity assay. NO concentration was represented by nitrite and determined by Griess reaction. Indomethacin inhibited IL-1 and NO production by rat microglia stimulated at the concentration of 0.1-10 mu mol/l. However, it did not show any inhibitory effect on TNF-alpha production by resting and LPS-stimulated rat microglia. The results suggest that the mechanism by which indomethacin might be beneficial in treatment of AD might be due to the inhibition IL-1 and NO production from microglia. (C) 1999 International Society for Immunopharmacology. Published by Elsevier Science Ltd. |
| WOS关键词 | TUMOR-NECROSIS-FACTOR ; ALZHEIMERS-DISEASE ; ANTIINFLAMMATORY DRUGS ; FACTOR-ALPHA ; MACROPHAGES ; MECHANISMS ; CYTOKINE ; INVITRO |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000079936200008 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274749]  |
| 专题 | 药物化学研究室 药理学第三研究室 药物制剂研究中心 |
| 通讯作者 | Li, XY |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, ZY,Li, XY. Inhibitory effects of indomethacin on interleukin-1 and nitric oxide production in rat microglia in vitro[J]. INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY,1999,21(3):219-225. |
| APA | Du, ZY,&Li, XY.(1999).Inhibitory effects of indomethacin on interleukin-1 and nitric oxide production in rat microglia in vitro.INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY,21(3),219-225. |
| MLA | Du, ZY,et al."Inhibitory effects of indomethacin on interleukin-1 and nitric oxide production in rat microglia in vitro".INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY 21.3(1999):219-225. |
入库方式： OAI收割
来源：上海药物研究所
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