Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease
文献类型：期刊论文
| 作者 | Huang, Shichao6; Mao, Jianxin4,5; Ding, Kan3 ; Zhou, Yue5; Zeng, Xianglu6,7; Yang, Wenjuan2,4,5; Wang, Peipei3,4; Zhao, Cun2,4,5; Yao, Jian3,4; Xia, Peng1
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| 刊名 | STEM CELL REPORTS
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| 出版日期 | 2017-01-10 |
| 卷号 | 8期号:1页码:84-94 |
| ISSN号 | 2213-6711 |
| DOI | 10.1016/j.stemcr.2016.12.007 |
| 文献子类 | Article |
| 英文摘要 | Promoting neurogenesis is a promising strategy for the treatment of cognition impairment associated with Alzheimer's disease (AD). Ganoderma lucidum is a revered medicinal mushroom for health-promoting benefits in the Orient. Here, we found that oral administration of the polysaccharides and water extract from G. lucidum promoted neural progenitor cell (NPC) proliferation to enhance neurogenesis and alleviated cognitive deficits in transgenic AD mice. G. lucidum polysaccharides (GLP) also promoted self-renewal of NPC in cell culture. Further mechanistic study revealed that GLP potentiated activation of fibroblast growth factor receptor 1 (FGFR1) and downstream extracellular signal- regulated kinase (ERK) and AKT cascades. Consistently, inhibition of FGFR1 effectively blocked the GLP-promoted NPC proliferation and activation of the downstream cascades. Our findings suggest that GLP could serve as a regenerative therapeutic agent for the treatment of cognitive decline associated with neurodegenerative diseases. |
| WOS关键词 | HIPPOCAMPAL NEUROGENESIS ; ADULT NEUROGENESIS ; GROWTH-FACTOR ; STEM-CELLS ; EXTRACT ; RAT ; MEDICINE ; NEURONS ; BRAIN ; BETA |
| 资助项目 | Science and Technology Commission of Shanghai Municipality[15JC1400202] ; National Key Research and Development Program of China Stem Cell and Translational Research[2016YFA0101200] ; National Key Research and Development Program of China Stem Cell and Translational Research[2016YFA0101202] ; Ministry of Science and Technology of China[2014CB965002] ; National Natural Science Foundation of China[31400690] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000396354800008 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275679]  |
| 专题 | 药理学第三研究室 国家新药筛选中心 |
| 通讯作者 | Pei, Gang |
| 作者单位 | 1.Shanghai Green Valley Pharmaceut Co Ltd, Shanghai 201200, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Univ Chinese Acad Sci, Grad Sch, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 5.Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 6.Tongji Univ, Shanghai Key Lab Signaling & Dis Res Lab Receptor, Sch Life Sci & Technol, Shanghai 200092, Peoples R China; 7.Tongji Univ, Sch Life Sci & Technol, Collaborat Innovat Ctr Brain Sci, Shanghai 200092, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Shichao,Mao, Jianxin,Ding, Kan,et al. Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease[J]. STEM CELL REPORTS,2017,8(1):84-94. |
| APA | Huang, Shichao.,Mao, Jianxin.,Ding, Kan.,Zhou, Yue.,Zeng, Xianglu.,...&Pei, Gang.(2017).Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease.STEM CELL REPORTS,8(1),84-94. |
| MLA | Huang, Shichao,et al."Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease".STEM CELL REPORTS 8.1(2017):84-94. |
入库方式： OAI收割
来源：上海药物研究所
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