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  4. 药理学第三研究室
Sulfated fucoidan FP08S2 inhibits lung cancer cell growth in vivo by disrupting angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling

文献类型：期刊论文

作者Chen, Huanjun1,2,3; Cong, Qifei1,2,3; Du, Zhenyun1,2,3; Liao, Wenfeng1,2,3; Zhang, Lei1,2,3; Yao, Yanli1,2,3; Ding, Kan1,2,3
刊名CANCER LETTERS
出版日期2016-11-01
卷号382期号:1页码:44-52
关键词Fucoidan Angiogenesis VEGF Lung cancer
ISSN号0304-3835
DOI10.1016/j.canlet.2016.08.020
文献子类Article
英文摘要Fucoidan may inhibit angiogenesis. However, its functional target molecule and the underlying mechanism are still vague. In the present study, we showed that sulfated fucoidan FP08S2 from Sargassum fusiforme inhibited tube formation as well as migration and invasion of human microvascular endothelial cells (HMEC-1). In addition, FP08S2 was confirmed to disrupt VEGF-induced angiogenesis both in vitro and in vivo. Further study indicated that FP08S2 could bind to both VEGF and VEGFR2 to interfere with VEGF-VEGFR2 interaction. Moreover, VEGFR2/Erk/VEGF signaling pathway was blocked by FP08S2 in HMEC-1 cells. Importantly, FP08S2 impeded the growth and microvessel formation of A549 cancer cell xenograft in nude mice. These results suggested that FP08S2 presented remarkable anti-angiogenic activity via blocking VEGF signaling and could be a potential novel leading compound to inhibit lung cancer cell growth. (C) 2016 Published by Elsevier Ireland Ltd.
WOS关键词HYPOXIA-INDUCIBLE FACTOR-1 ; TUMOR ANGIOGENESIS ; THERAPEUTIC IMPLICATIONS ; BROWN SEAWEEDS ; VEGF ; MECHANISMS ; RECEPTOR ; MICROENVIRONMENT ; TRANSDUCTION ; EXPRESSION
资助项目National Natural Science Foundation of China (NSFC) in China[31230022] ; Shanghai Foundation for Outstanding Academic Leaders in China[16XD1404500]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000386985800005
出版者ELSEVIER IRELAND LTD
源URL[http://119.78.100.183/handle/2S10ELR8/275839]  
专题药理学第三研究室
通讯作者Ding, Kan
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China;
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Chen, Huanjun,Cong, Qifei,Du, Zhenyun,et al. Sulfated fucoidan FP08S2 inhibits lung cancer cell growth in vivo by disrupting angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling[J]. CANCER LETTERS,2016,382(1):44-52.
APA Chen, Huanjun.,Cong, Qifei.,Du, Zhenyun.,Liao, Wenfeng.,Zhang, Lei.,...&Ding, Kan.(2016).Sulfated fucoidan FP08S2 inhibits lung cancer cell growth in vivo by disrupting angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling.CANCER LETTERS,382(1),44-52.
MLA Chen, Huanjun,et al."Sulfated fucoidan FP08S2 inhibits lung cancer cell growth in vivo by disrupting angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling".CANCER LETTERS 382.1(2016):44-52.

入库方式： OAI收割

来源：上海药物研究所

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