Rhodium(III)-Catalyzed Site-Selective C-H Alkylation and Arylation of Pyridones Using Organoboron Reagents
文献类型：期刊论文
| 作者 | Peng, Panfeng1,2; Wang, Jiang1 ; Jiang, Hualiang1,2; Liu, Hong1
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2016-10-21 |
| 卷号 | 18期号:20页码:5376-5379 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.6b02755 |
| 文献子类 | Article |
| 英文摘要 | In this study we developed a method for the pyridine-directed, rhodium-catalyzed, site-selective C-H alkylation and arylation of pyridones using commercially available trifluoroborate reagents. This simple and versatile transformation proceeded smoothly under relatively mild conditions with perfect site selectivity. The coupling groups in the boron reagents can be extended to primary alkyl, benzyl, and cycloalkyl. Moreover, direct C-H arylation products could also be obtained under similar conditions. |
| WOS关键词 | SINGLE-ELECTRON TRANSMETALATION ; C3-SELECTIVE DIRECT ALKYLATION ; ARYL BORONIC ACIDS ; ARYLBORON REAGENTS ; BOND ACTIVATION ; 2-PYRIDONES ; FUNCTIONALIZATION ; HETEROCYCLES ; DERIVATIVES ; CATALYSIS |
| 资助项目 | National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21602234] ; National Natural Science Foundation of China[81220108025] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000386187300048 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275849]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, 103 Wen Hua Rd, Shenyang 110016, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Panfeng,Wang, Jiang,Jiang, Hualiang,et al. Rhodium(III)-Catalyzed Site-Selective C-H Alkylation and Arylation of Pyridones Using Organoboron Reagents[J]. ORGANIC LETTERS,2016,18(20):5376-5379. |
| APA | Peng, Panfeng,Wang, Jiang,Jiang, Hualiang,&Liu, Hong.(2016).Rhodium(III)-Catalyzed Site-Selective C-H Alkylation and Arylation of Pyridones Using Organoboron Reagents.ORGANIC LETTERS,18(20),5376-5379. |
| MLA | Peng, Panfeng,et al."Rhodium(III)-Catalyzed Site-Selective C-H Alkylation and Arylation of Pyridones Using Organoboron Reagents".ORGANIC LETTERS 18.20(2016):5376-5379. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。