Enantioselective Assembly of Spirolactones through NHC-Catalyzed Remote gamma-Carbon Addition of Enals with Isatins
文献类型：期刊论文
| 作者 | Rong, Xianfeng1,2; Yao, Hong1; Xia, Wenjing1; Du, Yonglei1,2; Zhou, Yu1 ; Liu, Hong1
|
| 刊名 | ACS COMBINATORIAL SCIENCE
 |
| 出版日期 | 2016-05 |
| 卷号 | 18期号:5页码:220-224 |
| 关键词 | isatins gamma-carbon spirolactones |
| ISSN号 | 2156-8952 |
| DOI | 10.1021/acscombsci.5b00197 |
| 文献子类 | Article |
| 英文摘要 | A chiral N-heterocyclic carbene (NHC)-catalyzed formal [4+2] annulation of beta-methyl substituted enals with isatins was developed to construct six-membered spirolactones bearing highly congested quaternary carbon stereocentersin good yields and high enantioselectivities. The strategy realized a challenging remote gamma-carbon addition of enals and chiral control of beta-methyl substituted enals in the presence of the NHC catalyst only. |
| WOS关键词 | N-HETEROCYCLIC CARBENE ; SPIROCYCLIC OXINDOLE-DIHYDROPYRANONES ; COOPERATIVE CATALYSIS ; CONJUGATE UMPOLUNG ; SPIRO COMPOUNDS ; ALPHA,BETA-UNSATURATED ALDEHYDES ; QUATERNARY STEREOCENTERS ; ACID ; ACTIVATION ; ESTERS |
| 资助项目 | National Natural Science Foundation of China[81220108025] ; National Natural Science Foundation of China[21372235] ; Chinese National Programs for Fundamental Research and Development[2015CB910304] ; National ST Major Project[2014ZX09507002-001] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000375886800002 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276055]  |
| 专题 | 药物化学研究室 药理学第一研究室 |
| 通讯作者 | Zhou, Yu; Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Univ Sci & Technol China, Nano Sci & Technol Inst, 166 Ren Ai Rd, Suzhou 215123, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Rong, Xianfeng,Yao, Hong,Xia, Wenjing,et al. Enantioselective Assembly of Spirolactones through NHC-Catalyzed Remote gamma-Carbon Addition of Enals with Isatins[J]. ACS COMBINATORIAL SCIENCE,2016,18(5):220-224. |
| APA | Rong, Xianfeng,Yao, Hong,Xia, Wenjing,Du, Yonglei,Zhou, Yu,&Liu, Hong.(2016).Enantioselective Assembly of Spirolactones through NHC-Catalyzed Remote gamma-Carbon Addition of Enals with Isatins.ACS COMBINATORIAL SCIENCE,18(5),220-224. |
| MLA | Rong, Xianfeng,et al."Enantioselective Assembly of Spirolactones through NHC-Catalyzed Remote gamma-Carbon Addition of Enals with Isatins".ACS COMBINATORIAL SCIENCE 18.5(2016):220-224. |
入库方式： OAI收割
来源：上海药物研究所
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