Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme
文献类型：期刊论文
| 作者 | Cong, Qifei; Chen, Huanjun; Liao, Wenfeng; Xiao, Fei; Wang, Peipei ; Qin, Yi; Dong, Qun; Ding, Kan
|
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2016-01-20 |
| 卷号 | 136页码:899-907 |
| 关键词 | Sargassum fusiforme Fucoidan Structure Anti-angiogenic activity |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2015.09.087 |
| 文献子类 | Article |
| 英文摘要 | A fucoidan FP08S2 was isolated from the boiling-water extract of Sargassum fusiforme, purified by CaCl2 precipitation and chromatography on DEAE-cellulose and Sephacryl S-300. FP08S2 contained fucose, xylose, galactose, mannose, glucuronic acid, and 20.8% sulfate. The sulfate groups were attached to diverse positions of fucose, xylose, mannose, and galactose residues. The backbone of FP08S2 consisted of alternate 1,2-linked alpha-D-Manp and 1A-linked beta-D-GlcpA. Sugar composition analysis and ESI-MS revealed that the oligosaccharides from branches contained fucose, xylose, galactose, glucuronic acid and sulfate. FP08S2 could significantly inhibit tube formation and migration of human microvascular endothelial cells (HMEC-1) dose-dependently. These results suggested that the fucoidan FP08S2 from brown seaweeds S. fusiforme could be a potent anti-angiogenic agent. (C) 2015 Elsevier Ltd. All rights reserved. |
| WOS关键词 | BROWN SEAWEED ; HIZIKIA-FUSIFORME ; ANTICOAGULANT ACTIVITY ; CELLS ; POLYSACCHARIDES ; BIOACTIVITY ; ANTITUMOR ; GROWTH ; CANCER ; MICE |
| 资助项目 | National Natural Science Foundation of China (NSFC)[31230022] ; New Drug Creation and Manufacturing Program[2012ZX09301001-003] ; National Science Fund for Distinguished Young Scholars in China[81125025] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000365972000106 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276176]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Dong, Qun |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cong, Qifei,Chen, Huanjun,Liao, Wenfeng,et al. Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme[J]. CARBOHYDRATE POLYMERS,2016,136:899-907. |
| APA | Cong, Qifei.,Chen, Huanjun.,Liao, Wenfeng.,Xiao, Fei.,Wang, Peipei.,...&Ding, Kan.(2016).Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme.CARBOHYDRATE POLYMERS,136,899-907. |
| MLA | Cong, Qifei,et al."Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme".CARBOHYDRATE POLYMERS 136(2016):899-907. |
入库方式： OAI收割
来源：上海药物研究所
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