Small-Molecule Therapeutics for Ebola Virus (EBOV) Disease Treatment
文献类型：期刊论文
| 作者 | Izawa, Kunisuke4; Luis Acena, Jose1,5; Wang, Jiang3 ; Soloshonok, Vadim A.2,5; Liu, Hong3
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| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2016-01 |
| 期号 | 1页码:8-16 |
| 关键词 | Synthetic methods Medicinal chemistry Drug design Antiviral agents |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.201501158 |
| 文献子类 | Review |
| 英文摘要 | The current epidemic of Ebola virus (EBOV) hemorrhagic fever in sub-Saharan West-African countries, in terms of severity, is second only to the human immunodeficiency virus (HIV). Besides the strong pathogenicity of EBOV, the unprecedented fatality rates (up to 90%) are partially the result of a near total absence of any proper vaccines and therapeutics to combat the EBOV epidemic. This review highlights the recent progress in identification of purely chemical, small-molecule drugs of considerable potential to be used as effective therapeutics for prevention, diagnosis, and treatment of EBOV. In particular, we profile three compounds - favipiravir, BCX-4430, and brincidofovir - identified by the World Health Organization as high-priority targets. The detailed syntheses and modes of antiviral activity of these drugs are critically discussed. The major goal of this review is to encourage the chemistry community to focus research on this area of high social impact. |
| WOS关键词 | PURINE NUCLEOSIDE PHOSPHORYLASE ; STATE ANALOG INHIBITORS ; T-705 FAVIPIRAVIR ; PRACTICAL SYNTHESIS ; ANTIVIRAL ACTIVITY ; VIRAL-INFECTIONS ; WEST-AFRICA ; IN-VITRO ; CIDOFOVIR ; FILOVIRIDAE |
| 资助项目 | Basque Foundation for Science (IKER-BASQUE)[00000000] ; Basque Government[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000368022100002 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276262]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Univ Autonoma Madrid, Dept Organ Chem, E-28049 Madrid, Spain; 2.Basque Fdn Sci, IKERBASQUE, Bilbao 48011, Spain 3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China; 4.Hamari Chem Ltd, Higashi Yodogawa ku, Osaka 5330024, Japan; 5.Univ Basque Country UPV, Fac Chem, Dept Organ Chem 1, EHU, San Sebastian 20018, Spain; |
| 推荐引用方式 GB/T 7714 | Izawa, Kunisuke,Luis Acena, Jose,Wang, Jiang,et al. Small-Molecule Therapeutics for Ebola Virus (EBOV) Disease Treatment[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2016(1):8-16. |
| APA | Izawa, Kunisuke,Luis Acena, Jose,Wang, Jiang,Soloshonok, Vadim A.,&Liu, Hong.(2016).Small-Molecule Therapeutics for Ebola Virus (EBOV) Disease Treatment.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(1),8-16. |
| MLA | Izawa, Kunisuke,et al."Small-Molecule Therapeutics for Ebola Virus (EBOV) Disease Treatment".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .1(2016):8-16. |
入库方式： OAI收割
来源：上海药物研究所
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