A [4+1] Cyclative Capture Approach to 3H-Indole-N-oxides at Room Temperature by Rhodium(III)-Catalyzed C-H Activation
文献类型：期刊论文
| 作者 | Yang, Yaxi ; Wang, Xuan; Li, Yuanchao; Zhou, Bing
|
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2015-12-14 |
| 卷号 | 54期号:51页码:15400-15404 |
| 关键词 | C-H activation cyclizations diazo compounds heterocycles rhodium |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201508702 |
| 文献子类 | Article |
| 英文摘要 | The rhodium(III)-catalyzed [3+2] C-H cyclization of aniline derivatives and internal alkynes represents a useful contribution to straightforward synthesis of indoles. However, there is no report on the more challenging synthesis of pharmaceutically important N-hydroxyindoles and 3H-indole-N-oxides. Reported herein is the first rhodium(III)-catalyzed [4+1] C-H oxidative cyclization of nitrones with diazo compounds to access 3H-indole-N-oxides. More significantly, this reaction proceeds at room temperature and has been extended to the synthesis of N-hydroxyindoles and N-hydroxyindolines. |
| WOS关键词 | NONREARRANGED MONOTERPENOID UNIT ; OXIDIZING DIRECTING GROUP ; SIMPLE INDOLE ALKALOIDS ; OXYGEN-ATOM TRANSFER ; N-OXIDE DERIVATIVES ; INTERNAL ALKYNES ; BOND ACTIVATION ; DIAZO-COMPOUNDS ; EFFICIENT SYNTHESIS ; CARBENOID FUNCTIONALIZATION |
| 资助项目 | National Natural Science Foundation of China[21302200] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000368058500010 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276283]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Zhou, Bing |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yaxi,Wang, Xuan,Li, Yuanchao,et al. A [4+1] Cyclative Capture Approach to 3H-Indole-N-oxides at Room Temperature by Rhodium(III)-Catalyzed C-H Activation[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(51):15400-15404. |
| APA | Yang, Yaxi,Wang, Xuan,Li, Yuanchao,&Zhou, Bing.(2015).A [4+1] Cyclative Capture Approach to 3H-Indole-N-oxides at Room Temperature by Rhodium(III)-Catalyzed C-H Activation.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(51),15400-15404. |
| MLA | Yang, Yaxi,et al."A [4+1] Cyclative Capture Approach to 3H-Indole-N-oxides at Room Temperature by Rhodium(III)-Catalyzed C-H Activation".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.51(2015):15400-15404. |
入库方式： OAI收割
来源：上海药物研究所
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