Asymmetric Synthesis of (2S,3S)-alpha-(1-Oxoisoindolin-3-yl)glycines under Low-Basicity "Kinetic" Control
文献类型：期刊论文
| 作者 | Li, Tingting1,3; Zhou, Shengbin3; Wang, Jiang3 ; Acena, Jose Luis2; Soloshonok, Vadim A.4; Liu, Hong1,3
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2015-11-20 |
| 卷号 | 80期号:22页码:11275-11280 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.5b01730 |
| 文献子类 | Article |
| 英文摘要 | The previously illusive (2S,3S)-configured alpha-(1-oxoisoindolin-3-yl)glycines can be prepared under mild DBU-catalyzed, low-basicity conditions. The overall process includes a cascade of aldol addition, cyclization, rearrangement, and conjugate addition reactions, leading to the target products with moderate to good chemical yields and diasteroselectivity. |
| WOS关键词 | ALPHA-AMINO-ACIDS ; NUCLEOPHILIC GLYCINE ; NI(II) COMPLEXES ; STEREOSELECTIVE-SYNTHESIS ; CHIRAL NI(II)-COMPLEX ; ADDITION-REACTIONS ; MICHAEL ADDITION ; ALDOL REACTIONS ; PEPTIDOMIMETICS ; INTERCONVERSION |
| 资助项目 | National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81025017] ; National S&T Major Projects[2012ZX09103101-072] ; National S&T Major Projects[2012ZX09301001-005] ; National S&T Major Projects[2013ZX09507-001] ; National S&T Major Projects[2014ZX09507002001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000365462600006 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276316]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Soloshonok, Vadim A. |
| 作者单位 | 1.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China; 2.Univ Basque Country, UPV EHU, Fac Chem, Dept Organ Chem 1, San Sebastian 20018, Spain; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China; 4.Basque Fdn Sci, Ikerbasque, Bilbao 48011, Spain |
| 推荐引用方式 GB/T 7714 | Li, Tingting,Zhou, Shengbin,Wang, Jiang,et al. Asymmetric Synthesis of (2S,3S)-alpha-(1-Oxoisoindolin-3-yl)glycines under Low-Basicity "Kinetic" Control[J]. JOURNAL OF ORGANIC CHEMISTRY,2015,80(22):11275-11280. |
| APA | Li, Tingting,Zhou, Shengbin,Wang, Jiang,Acena, Jose Luis,Soloshonok, Vadim A.,&Liu, Hong.(2015).Asymmetric Synthesis of (2S,3S)-alpha-(1-Oxoisoindolin-3-yl)glycines under Low-Basicity "Kinetic" Control.JOURNAL OF ORGANIC CHEMISTRY,80(22),11275-11280. |
| MLA | Li, Tingting,et al."Asymmetric Synthesis of (2S,3S)-alpha-(1-Oxoisoindolin-3-yl)glycines under Low-Basicity "Kinetic" Control".JOURNAL OF ORGANIC CHEMISTRY 80.22(2015):11275-11280. |
入库方式： OAI收割
来源：上海药物研究所
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