Recyclable Ligands for the Non-Enzymatic Dynamic Kinetic Resolution of Challenging -Amino Acids
文献类型：期刊论文
| 作者 | Nian, Yong3,4; Wang, Jiang4 ; Zhou, Shengbin4; Wang, Shuni4; Moriwaki, Hiroki5; Kawashima, Aki5; Soloshonok, Vadim A.1,2; Liu, Hong3,4
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| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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| 出版日期 | 2015-10-26 |
| 卷号 | 54期号:44页码:12918-12922 |
| 关键词 | amino acids enantioselectivity kinetic resolution N ligands nickel |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201507273 |
| 文献子类 | Article |
| 英文摘要 | Structurally simple and inexpensive chiral tridentate ligands were employed for substantially advancing the purely chemical dynamic kinetic resolution (DKR) of unprotected racemic tailor-made -amino acids (TM--AAs), enabling the first DKR of TM--AAs bearing tertiary alkyl chains as well as multiple unprotected functional groups. Owing to the operationally convenient conditions, virtually complete stereoselectivity, and full recyclability of the source of chirality, this method should find wide applications for the preparation of TM--AAs, especially on large scale. |
| WOS关键词 | NUCLEOPHILIC GLYCINE EQUIVALENTS ; PHASE-TRANSFER CATALYSIS ; MICHAEL ADDITION-REACTIONS ; ALPHA-AMINO ; ASYMMETRIC-SYNTHESIS ; NI(II) COMPLEXES ; STEREOSELECTIVE-SYNTHESIS ; EFFICIENT SYNTHESIS ; R INTERCONVERSION ; NEW-GENERATION |
| 资助项目 | National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[81220108025] ; National Natural Science Foundation of China[81302633] ; National Natural Science Foundation of China[21472209] ; National Natural Science Foundation of China[91229204] ; National High Technology Research and Development Program of China[2012AA020302] ; Chinese National Programs for Fundamental Research and Development[2015CB910304] ; National Basic Research Program of China[2012CB518005] ; National S&T Major Projects[2012ZX09103101-072] ; National S&T Major Projects[2012ZX09301001-005] ; National S&T Major Projects[2013ZX09507-001] ; National S&T Major Projects[2014ZX09507002-001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000363423900011 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276353]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Soloshonok, Vadim A. |
| 作者单位 | 1.Ikerbasque, Basque Fdn Sci, Bilbao 48013, Spain 2.Univ Basque Country, UPV EHU, Dept Organ Chem 1, Fac Chem, San Sebastian 20018, Spain; 3.China Pharmaceut Univ Jiangsu, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China; 4.Chinese Acad Sci, Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 5.Hamari Chem Ltd, Osaka 5330024, Japan; |
| 推荐引用方式 GB/T 7714 | Nian, Yong,Wang, Jiang,Zhou, Shengbin,et al. Recyclable Ligands for the Non-Enzymatic Dynamic Kinetic Resolution of Challenging -Amino Acids[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(44):12918-12922. |
| APA | Nian, Yong.,Wang, Jiang.,Zhou, Shengbin.,Wang, Shuni.,Moriwaki, Hiroki.,...&Liu, Hong.(2015).Recyclable Ligands for the Non-Enzymatic Dynamic Kinetic Resolution of Challenging -Amino Acids.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(44),12918-12922. |
| MLA | Nian, Yong,et al."Recyclable Ligands for the Non-Enzymatic Dynamic Kinetic Resolution of Challenging -Amino Acids".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.44(2015):12918-12922. |
入库方式： OAI收割
来源：上海药物研究所
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