Asymmetric Synthesis of Spirooxindoles via Organocascade Strategies
文献类型：期刊论文
| 作者 | Xiao Yonglong2; Zhou Yu1 ; Wang Jiang1; Wang Jiaxin2; Liu Hong1
|
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2015-10 |
| 卷号 | 35期号:10页码:2035-2048 |
| 关键词 | spirooxindoles asymmetric catalysis organocascade |
| ISSN号 | 0253-2786 |
| DOI | 10.6023/cjoc201504045 |
| 文献子类 | Review |
| 英文摘要 | The spirooxindoles have broad and promising activities in various therapeutic areas, and become a privileged skeleton for drug discovery. Therefore, the development of some simple and efficient strategies to build these sophisticated scaffolds has become one of the most widespread concerns. However, the traditional methods are limited by the separation and purification of intermediates, the functional group protection and de-protection. Recently, the cascade strategies have shown special advantages in the synthesis of optically active natural products and complex molecules, many related studies have been reported. This review summarizes the enantioselective synthesis of spirooxindoles via cascade strategies in the past five years and organized on the basis of four types of starting materials: unsaturated oxindole derivatives, C(3)-substituted oxindoles, C(3)-unsubstituted oxindoles and nonoxindoles. |
| WOS关键词 | N-HETEROCYCLIC CARBENE ; HIGHLY ENANTIOSELECTIVE SYNTHESIS ; 6-MEMBERED SPIROCYCLIC OXINDOLES ; BAYLIS-HILLMAN CARBONATES ; 1,3-DIPOLAR CYCLOADDITION ; CONSECUTIVE STEREOCENTERS ; STEREOSELECTIVE-SYNTHESIS ; PHOSPHINES SYNTHESIS ; 3+2 ANNULATION ; FACILE ACCESS |
| 资助项目 | National Natural Science Foundation of China[21372235] |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5566357 |
| WOS记录号 | WOS:000365833100002 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276376]  |
| 专题 | 药物化学研究室 药理学第一研究室 |
| 通讯作者 | Xiao Yonglong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.China Pharmaceut Univ, Jiangsu Prov Key Lab Drug Design & Optimizat Med, Nanjing 210009, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xiao Yonglong,Zhou Yu,Wang Jiang,et al. Asymmetric Synthesis of Spirooxindoles via Organocascade Strategies[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2015,35(10):2035-2048. |
| APA | Xiao Yonglong,Zhou Yu,Wang Jiang,Wang Jiaxin,&Liu Hong.(2015).Asymmetric Synthesis of Spirooxindoles via Organocascade Strategies.CHINESE JOURNAL OF ORGANIC CHEMISTRY,35(10),2035-2048. |
| MLA | Xiao Yonglong,et al."Asymmetric Synthesis of Spirooxindoles via Organocascade Strategies".CHINESE JOURNAL OF ORGANIC CHEMISTRY 35.10(2015):2035-2048. |
入库方式： OAI收割
来源：上海药物研究所
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