The facile construction of the phthalazin-1(2H)-one scaffold via copper-mediated C-H(sp(2))/C-H(sp) coupling under mild conditions
文献类型：期刊论文
| 作者 | Zhu, Wei; Wang, Bao; Zhou, Shengbin; Liu, Hong
|
| 刊名 | BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2015-09-14 |
| 卷号 | 11页码:1624-1631 |
| 关键词 | C-H activation copper phthalazin-1(2H)-one |
| ISSN号 | 1860-5397 |
| DOI | 10.3762/bjoc.11.177 |
| 文献子类 | Article |
| 英文摘要 | A novel strategy for the construction of the phthalazin-1(2H)-one scaffold has been developed by means of a copper-mediated cascade C-H/C-H coupling and intramolecular annulations and a subsequent facile hydrazinolysis. This C-H activation transformation proceeds smoothly with wide generality, good functional tolerance and high stereo-and regioselectivity under mild conditions. Through the removal of the directing group, the resulting moiety could easily be transformed into the phthalazin-1(2H)-one scaffold, which is known to be a privileged moiety and a bioactive nucleus in pharmaceuticals. |
| WOS关键词 | BENZOIC-ACID DERIVATIVES ; TERMINAL ALKYNES ; FUNCTIONALIZATION ; ALKYNYLATION ; INHIBITOR ; SYSTEM ; CANCER ; BONDS |
| 资助项目 | National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81025017] ; Program of Shanghai Subject Chief Scientist[12 XD1407100] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000361173900001 |
| 出版者 | BEILSTEIN-INSTITUT |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276398]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Wei,Wang, Bao,Zhou, Shengbin,et al. The facile construction of the phthalazin-1(2H)-one scaffold via copper-mediated C-H(sp(2))/C-H(sp) coupling under mild conditions[J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,2015,11:1624-1631. |
| APA | Zhu, Wei,Wang, Bao,Zhou, Shengbin,&Liu, Hong.(2015).The facile construction of the phthalazin-1(2H)-one scaffold via copper-mediated C-H(sp(2))/C-H(sp) coupling under mild conditions.BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,11,1624-1631. |
| MLA | Zhu, Wei,et al."The facile construction of the phthalazin-1(2H)-one scaffold via copper-mediated C-H(sp(2))/C-H(sp) coupling under mild conditions".BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 11(2015):1624-1631. |
入库方式： OAI收割
来源：上海药物研究所
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