A new strategy for synthesis of branched cyclic peptide by Asn side-chain hydrazide ligation
文献类型：期刊论文
| 作者 | Lu, Jian1; Tian, Xiao-Bo1,2; Huang, Wei1 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2015-08 |
| 卷号 | 26期号:8页码:946-950 |
| 关键词 | Branched cyclic peptide Asn side-chain ligation Hydrazide ligation Neopeptide |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2015.05.016 |
| 文献子类 | Article |
| 英文摘要 | Here, we report a new strategy for rapid synthesis of branched peptide by side-chain hydrazide ligation at Asn. The hydrazide was converted to thioester at Asn side chain by NaNO2 and thiol reagent, and sequential ligation with an N-terminus Cys-peptide efficiently afforded the branched peptide. A branched cyclic peptide was successfully synthesized by side-chain ligation with a two-Cys-peptide and formation of a disulfide bond. This approach provides a new way for expeditious synthesis of branched peptides and facilitates the design of neopeptides as functional bio-mimics. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| WOS关键词 | PROTEIN CHEMICAL-SYNTHESIS ; SOLID-PHASE SYNTHESIS ; CLICK CHEMISTRY ; V3 LOOP ; INFECTION ; COMPLEX |
| 资助项目 | National Natural Science Foundation of China (NNSFC)[21372238] ; National 1000-Young-Talent Program of China[00000000] ; Shanghai Pujiang Talent Program[13PJ1410200] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5513204 |
| WOS记录号 | WOS:000360516700006 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276445]  |
| 专题 | 生物技术药物研发中心（筹） 药物安全性评价中心 |
| 通讯作者 | Huang, Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 2.Nanchang Univ, Coll Med, Nanchang 330006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Jian,Tian, Xiao-Bo,Huang, Wei. A new strategy for synthesis of branched cyclic peptide by Asn side-chain hydrazide ligation[J]. CHINESE CHEMICAL LETTERS,2015,26(8):946-950. |
| APA | Lu, Jian,Tian, Xiao-Bo,&Huang, Wei.(2015).A new strategy for synthesis of branched cyclic peptide by Asn side-chain hydrazide ligation.CHINESE CHEMICAL LETTERS,26(8),946-950. |
| MLA | Lu, Jian,et al."A new strategy for synthesis of branched cyclic peptide by Asn side-chain hydrazide ligation".CHINESE CHEMICAL LETTERS 26.8(2015):946-950. |
入库方式： OAI收割
来源：上海药物研究所
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