Structural elucidation of a polysaccharide from Chrysanthemum morifolium flowers with anti-angiogenic activity
文献类型：期刊论文
| 作者 | Zheng, Changping1,2; Dong, Qun1; Du, Zhenyun1; Wang, Peipei1 ; Ding, Kan1
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2015-08 |
| 卷号 | 79页码:674-680 |
| 关键词 | Chrysanthemum morifolium Polysaccharide Anti-angiogenesis |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2015.04.026 |
| 文献子类 | Article |
| 英文摘要 | The flowers of Chrysanthemum morifolium were extracted with 5% sodium hydroxide, yielding a neutral polysaccharide (JHB0S2) with a molecular weight of 16 kDa by anion-exchange chromatography on a DEAE-cellulose column and gel permeation chromatography on a Sephacryl S-200 HR column. JHB0S2 was found to contain glucose, xylose, arabinose and galactose in molar ratio of 2.9:2.3:1.0:1.2. Through the linkage analysis, partial acid hydrolysis and NMR spectra and so forth, indicated that its back-bone consisted of 1,4-linked beta-Glcp, nearly 50% of which was substituted at O-6 by 1,2-linked alpha-Xylp terminated with Galp or Xylp. Furthermore, some of 1,2-linked alpha-Xylp was substituted at O-4 by alpha-Araf-(1 -> 5)-alpha-Araf-(1 -> 6)-beta-Galp. The biological test showed that JHB0S2 could inhibit the tube formation of HMEC-1 cells. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS关键词 | PLATYCODON-GRANDIFLORUM ; ANTIANGIOGENIC ACTIVITY ; GRIFOLA-FRONDOSA ; ARABINOGALACTAN ; OLIGOSACCHARIDES ; BIOACTIVITY ; XYLOGLUCAN ; INHIBITION ; FEATURES ; EXTRACT |
| 资助项目 | National Natural Science Foundation of China (NSFC)[31230022] ; New Drug Creation and Manufacturing Program[2012ZX09301001-003] ; National Science Fund for Distinguished Young Scholars in China[81125025] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000359166300086 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276449]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Dong, Qun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Glycobiol & Glycochem Lab, Shanghai 201203, Peoples R China; 2.Nanchang Univ, Coll Pharm, Nanchang 330000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Changping,Dong, Qun,Du, Zhenyun,et al. Structural elucidation of a polysaccharide from Chrysanthemum morifolium flowers with anti-angiogenic activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2015,79:674-680. |
| APA | Zheng, Changping,Dong, Qun,Du, Zhenyun,Wang, Peipei,&Ding, Kan.(2015).Structural elucidation of a polysaccharide from Chrysanthemum morifolium flowers with anti-angiogenic activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,79,674-680. |
| MLA | Zheng, Changping,et al."Structural elucidation of a polysaccharide from Chrysanthemum morifolium flowers with anti-angiogenic activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 79(2015):674-680. |
入库方式： OAI收割
来源：上海药物研究所
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