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Inhibitory Effects of (2 ' R)-2 ',3 '-dihydro-2 '-(1-hydroxy-1-methylethyl)-2,6 '-bibenzofuran-6,4 '-diol on Mushroom Tyrosinase and Melanogenesis in B16-F10 Melanoma Cells

文献类型：期刊论文

作者Zhu, Jing-jie1; Yan, Gui-rui1; Xu, Zhi-jian1; Hu, Xiao2; Wang, Gai-hong1; Wang, Ting1; Zhu, Wei-liang1; Hou, Ai-jun2; Wang, He-yao1
刊名PHYTOTHERAPY RESEARCH
出版日期2015-07
卷号29期号:7页码:1040-1045
关键词(2 ' R)-2 ' 3 '-dihydro-2 '-(1-hydroxy-1-methylethyl)-2,6 '-bibenzofuran-6,4 '-diol tyrosinase inhibitor melanogenesis Morus notabilis Moraceae
ISSN号0951-418X
DOI10.1002/ptr.5344
文献子类Article
英文摘要(2 ' R)-2 ',3 '-Dihydro-2 '-(1-hydroxy-1-methylethyl)-2,6 '-bibenzofuran-6,4 '-diol (DHMB) is a natural compound extracted from Morus notabilis. It was found that DHMB acts as a competitive inhibitor against mushroom tyrosinase with a Ki value of 14.77 mu M. Docking results further indicated that it could form strong interactions with one copper ion with a distance of 2.7 angstrom, suggesting the mechanism of inhibition might be due to chelating copper ions in the active site. Furthermore, melanin production in B16-F10 murine melanoma cells was significantly inhibited by DHMB in a concentration-dependent manner without cytotoxicity. The results of western blotting also showed that DHMB decreased 3-isobuty-1-methxlzanthine-induced mature tyrosinase expression. Taken together, these findings indicated that DHMB may be a new promising pigmentation-altering agent for agriculture, cosmetic, and therapeutic applications. Copyright (c) 2015 John Wiley & Sons, Ltd.
WOS关键词SKIN PIGMENTATION ; KOJIC ACID ; TRANSCRIPTION FACTOR ; MECHANISM ; BIOSYNTHESIS ; MELANOCYTES ; DOCKING ; PATHWAY ; GLIDE
资助项目Shanghai Natural Science Foundation[14ZR1447700] ; National Marine '863' Project[2011AA09070102] ; Shanghai Science and Technology Innovation Program[08431900800] ; National Science and Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2013ZX09103001-001]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000357855300011
出版者WILEY-BLACKWELL
源URL[http://119.78.100.183/handle/2S10ELR8/276478]  
专题药理学第三研究室
通讯作者Wang, He-yao
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
2.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Jing-jie,Yan, Gui-rui,Xu, Zhi-jian,et al. Inhibitory Effects of (2 ' R)-2 ',3 '-dihydro-2 '-(1-hydroxy-1-methylethyl)-2,6 '-bibenzofuran-6,4 '-diol on Mushroom Tyrosinase and Melanogenesis in B16-F10 Melanoma Cells[J]. PHYTOTHERAPY RESEARCH,2015,29(7):1040-1045.
APA Zhu, Jing-jie.,Yan, Gui-rui.,Xu, Zhi-jian.,Hu, Xiao.,Wang, Gai-hong.,...&Wang, He-yao.(2015).Inhibitory Effects of (2 ' R)-2 ',3 '-dihydro-2 '-(1-hydroxy-1-methylethyl)-2,6 '-bibenzofuran-6,4 '-diol on Mushroom Tyrosinase and Melanogenesis in B16-F10 Melanoma Cells.PHYTOTHERAPY RESEARCH,29(7),1040-1045.
MLA Zhu, Jing-jie,et al."Inhibitory Effects of (2 ' R)-2 ',3 '-dihydro-2 '-(1-hydroxy-1-methylethyl)-2,6 '-bibenzofuran-6,4 '-diol on Mushroom Tyrosinase and Melanogenesis in B16-F10 Melanoma Cells".PHYTOTHERAPY RESEARCH 29.7(2015):1040-1045.

入库方式： OAI收割

来源：上海药物研究所

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