Preparation of 2-aryl derivatives of tanshinone I through a palladium-catalyzed C-sp2-H activation/arylation approach
文献类型：期刊论文
| 作者 | Jiao, Mingkun; Ding, Chunyong ; Zhang, Ao
|
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2015-05-20 |
| 卷号 | 56期号:21页码:2799-2802 |
| 关键词 | Tanshinone I Anticancer Palladium Direct arylation C-H activation |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2015.04.040 |
| 文献子类 | Article |
| 英文摘要 | A facile and efficient synthetic approach under the catalyst system of Pd(OAc)(2)/KOAc/TBAB/DMF was developed allowing for rapid preparation of 2-arylation derivatives of the natural product tanshinone I. This approach was featured by palladium-catalyzed C-C coupling through direct C-sp2-H activation at the a-position of the furan ring of tanshinone I. Compared to the literature procedures, our protocol exhibited better atom-economy and much improved yields. (C) 2015 Elsevier Ltd. All rights reserved. |
| WOS关键词 | SALVIA-MILTIORRHIZA BUNGE ; C-H FUNCTIONALIZATION ; BOND ACTIVATION ; CANCER CELLS ; CRYPTOTANSHINONE ; HETEROCYCLES ; INHIBITION ; ARYLATIONS ; THIOPHENE ; APOPTOSIS |
| 资助项目 | National Natural Science Foundation of China[81402790] ; Pujiang Talent Project from Shanghai Commission of Science and Technology[14PJ1410700] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000355036400038 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276523]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Ding, Chunyong |
| 作者单位 | Chinese Acad Sci, SIMM, SOMCL, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiao, Mingkun,Ding, Chunyong,Zhang, Ao. Preparation of 2-aryl derivatives of tanshinone I through a palladium-catalyzed C-sp2-H activation/arylation approach[J]. TETRAHEDRON LETTERS,2015,56(21):2799-2802. |
| APA | Jiao, Mingkun,Ding, Chunyong,&Zhang, Ao.(2015).Preparation of 2-aryl derivatives of tanshinone I through a palladium-catalyzed C-sp2-H activation/arylation approach.TETRAHEDRON LETTERS,56(21),2799-2802. |
| MLA | Jiao, Mingkun,et al."Preparation of 2-aryl derivatives of tanshinone I through a palladium-catalyzed C-sp2-H activation/arylation approach".TETRAHEDRON LETTERS 56.21(2015):2799-2802. |
入库方式： OAI收割
来源：上海药物研究所
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