An arabinogalactan from flowers of Panax notoginseng inhibits angiogenesis by BMP2/Smad/Id1 signaling
文献类型：期刊论文
| 作者 | Wang, Peipei1,3 ; Zhang, Lei1,3; Yao, Jian1; Shi, Yikang2; Li, Ping3; Ding, Kan1
|
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2015-05-05 |
| 卷号 | 121页码:328-335 |
| 关键词 | Arabinogalactan Panax notoginseng Antiangiogenesis BMP2 |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2014.11.073 |
| 文献子类 | Article |
| 英文摘要 | Angiogenesis plays an essential role in tumor development. Blocking angiogenesis in tumor has become a promising tactic in limiting cancer progression. Here, an arabinogalactan polysaccharide, RN1 was isolated from flowers of Partax notoginseng. Its structure was determined to possess a backbone of 1,6-linked Galp branched at C3 by side 1,3-linked Galp, with branches attached at position O-3 of it. The branches mainly contained 1,5-linked, 13,5-linked, terminal Arabinose and terminal Galactose. RN1 could inhibit microvessel formation in the BxPC-3 pancreatic cancer cell xenograft tumor in nude mice. The antiangiogenesis assay showed that RN1 could reduce the migratory activity of endothelial cells and their ability of tube formation on matrigel, but no effect on endothelial cells growth. Further studies revealed that RN1 could inhibit BMP2/Smad1/5/8/Id1 signaling. All those data indicated the RN1 had an antiangiogenic effect via BMP2 signaling and could be a potential novel inhibitor of angiogenesis. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | BONE MORPHOGENETIC PROTEIN ; BIP. EX WALP ; STRUCTURAL-CHARACTERIZATION ; IMMUNOMODULATING ACTIVITY ; CANCER-CELLS ; POLYSACCHARIDES ; TARGETS ; LEAVES ; ROOTS ; ID1 |
| 资助项目 | National Natural Science Foundation of China[31230022] ; New Drug Creation and Manufacturing Program[2012ZX09301001-003] ; National Science Fund for Distinguished Young Scholars in China[81125025] ; Shanghai Research Program[13ZR1447500] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000350182400042 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276539]  |
| 专题 | 药理学第三研究室 国家新药筛选中心 |
| 通讯作者 | Li, Ping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China; 2.Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250100, Peoples R China 3.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Peipei,Zhang, Lei,Yao, Jian,et al. An arabinogalactan from flowers of Panax notoginseng inhibits angiogenesis by BMP2/Smad/Id1 signaling[J]. CARBOHYDRATE POLYMERS,2015,121:328-335. |
| APA | Wang, Peipei,Zhang, Lei,Yao, Jian,Shi, Yikang,Li, Ping,&Ding, Kan.(2015).An arabinogalactan from flowers of Panax notoginseng inhibits angiogenesis by BMP2/Smad/Id1 signaling.CARBOHYDRATE POLYMERS,121,328-335. |
| MLA | Wang, Peipei,et al."An arabinogalactan from flowers of Panax notoginseng inhibits angiogenesis by BMP2/Smad/Id1 signaling".CARBOHYDRATE POLYMERS 121(2015):328-335. |
入库方式： OAI收割
来源：上海药物研究所
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