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Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions

文献类型：期刊论文

作者Wang, Hengshuai1; Jiao, Shengchao1,2; Chen, Kerong1; Zhang, Xu1; Zhao, Linxiang2; Liu, Dan2; Zhou, Yu1; Liu, Hong1
刊名BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
出版日期2015-03-30
卷号11页码:416-424
关键词heterocyclic molecules intramolecular alkyne hydroamination silver
ISSN号1860-5397
DOI10.3762/bjoc.11.47
文献子类Article
英文摘要We report a synthetic methodology for the construction of the fused heterocyclic compounds pyrido[2,1-b]quinazolin-9(1H)-ones and pyrrolo[2,1-b]quinazolin-9(1H)-ones through an AgOTf-catalyzed intramolecular alkyne hydroamination reaction. The methodology is applicable to a wide scope of substrates and produces a series of fused quinazolinone heterocycles in good to excellent yields.
WOS关键词ENANTIOSELECTIVE HYDROAMINATION ; IMINOKETENE CYCLOADDITION ; CATALYZED HYDROAMINATION ; EFFICIENT SYNTHESIS ; ACRIDONE ALKALOIDS ; ALKENES ; HETEROCYCLES ; GOLD ; QUINAZOLINE ; DERIVATIVES
资助项目National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[21372235] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304] ; National High Technology Research and Development Program of China[2012AA020302] ; National Basic Research Program of China[2012CB518005] ; National S&T Major Projects[2012ZX09103101-072] ; National S&T Major Projects[2014ZX09507002-001] ; National S&T Major Projects[2013ZX09507-001]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000351896200001
出版者BEILSTEIN-INSTITUT
源URL[http://119.78.100.183/handle/2S10ELR8/276595]  
专题药物化学研究室
药理学第一研究室
通讯作者Zhou, Yu
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China;
2.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Hengshuai,Jiao, Shengchao,Chen, Kerong,et al. Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions[J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,2015,11:416-424.
APA Wang, Hengshuai.,Jiao, Shengchao.,Chen, Kerong.,Zhang, Xu.,Zhao, Linxiang.,...&Liu, Hong.(2015).Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions.BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,11,416-424.
MLA Wang, Hengshuai,et al."Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions".BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 11(2015):416-424.

入库方式： OAI收割

来源：上海药物研究所

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