A beta regulation-based multitarget strategy for drug discovery against Alzheimer's disease
文献类型：期刊论文
| 作者 | Guo, Xiaodan; Jiang, Wei; Li, Chenjing; Zhu, Zhiyuan; Shen, Xu
|
| 刊名 | REVIEWS IN THE NEUROSCIENCES
 |
| 出版日期 | 2015-02 |
| 卷号 | 26期号:1页码:13-30 |
| 关键词 | acetyl cholinesterase Alzheimer's disease autophagy beta-amyloid ER stress lifespan multitarget oxidative stress secretase tau protein |
| ISSN号 | 0334-1763 |
| DOI | 10.1515/revneuro-2014-0064 |
| 文献子类 | Article |
| 英文摘要 | Alzheimer's disease (AD) is a progressively neurodegenerative disease that eventually leads to the irreversible loss of neurons and intellectual abilities, including cognition and memory. AD has become the most common cause of dementia in aged people, and the ill-defined pathogenesis of AD is seriously impeding the current drug discovery against this disease. To date, there is still a lack of etiologically therapeutic drugs for AD, although some symptomatic treatments have been successfully developed. The beta-amyloid (A beta)-induced neurodegeneration is determined as the main pathogenesis of AD, and by targeting the regulation of A beta in production inhibition or clearance promotion, many active agents have been designed potentially for AD treatment, but no drug has yet been approved in clinical use. Actually, AD has a complex pathogenic mechanism that involves multiple aberrant signaling genes and pathways, and the idea of 'single target' for anti-AD drug research is thus full of challenges. Recently, with a deep understanding of AD pathogeneses and the development of advanced pharmacological techniques, 'multiple target'-based strategy has been widely applied for the drug discovery against this disease, and many promising results have been achieved. Here, we review the recent multitarget strategies for the drug discovery in the treatment of AD by focusing on the involvement of A beta regulation. |
| WOS关键词 | AMYLOID PRECURSOR PROTEIN ; IMPROVES COGNITIVE IMPAIRMENT ; CHRONIC CEREBRAL HYPOPERFUSION ; AMELIORATES MEMORY IMPAIRMENT ; CYCLIN-DEPENDENT KINASE-5 ; RAT HIPPOCAMPAL-NEURONS ; CENTRAL-NERVOUS-SYSTEM ; APOLIPOPROTEIN-E ; PTYCHOPETALUM-OLACOIDES ; INDUCED APOPTOSIS |
| 资助项目 | National Science & Technology Major Project[2012ZX09301001-004] ; National Natural Science Foundation of China[81373462] ; National Natural Science Foundation of China[81473141] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000350396700002 |
| 出版者 | WALTER DE GRUYTER GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276651]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Zhu, Zhiyuan |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Xiaodan,Jiang, Wei,Li, Chenjing,et al. A beta regulation-based multitarget strategy for drug discovery against Alzheimer's disease[J]. REVIEWS IN THE NEUROSCIENCES,2015,26(1):13-30. |
| APA | Guo, Xiaodan,Jiang, Wei,Li, Chenjing,Zhu, Zhiyuan,&Shen, Xu.(2015).A beta regulation-based multitarget strategy for drug discovery against Alzheimer's disease.REVIEWS IN THE NEUROSCIENCES,26(1),13-30. |
| MLA | Guo, Xiaodan,et al."A beta regulation-based multitarget strategy for drug discovery against Alzheimer's disease".REVIEWS IN THE NEUROSCIENCES 26.1(2015):13-30. |
入库方式： OAI收割
来源：上海药物研究所
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