Site-specific indolation of proline-based peptides via copper(II)-catalyzed oxidative coupling of tertiary amine N-oxides
文献类型：期刊论文
| 作者 | Wu, Xiaowei; Zhang, Dengyou; Zhou, Shengbin; Gao, Feng; Liu, Hong
|
| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2015 |
| 卷号 | 51期号:63页码:12571-12573 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/c5cc03706a |
| 文献子类 | Article |
| 英文摘要 | The first site-specific and purely chemical method for modifying proline-based peptides was developed via a convenient, copper-catalyzed oxidative coupling of tertiary amine N-oxides with indoles. This novel approach features high regioselectivity and diastereo-selectivity, mild conditions, and compatibility with various functional groups. In addition, a simplified process was realized in one pot and two steps via in situ oxidative coupling of tertiary amine and indoles. |
| WOS关键词 | C-H BONDS ; TERMINAL FUNCTIONALIZATION ; GLYCINE DERIVATIVES ; AFFINITY ; COMPLEX ; ALKYNES |
| 资助项目 | National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81025017] ; National S&T Major Projects[2012ZX09103101-072] ; National S&T Major Projects[2012ZX09301001-005] ; National S&T Major Projects[2013ZX09507-001] ; National S&T Major Projects[2014ZX09507002001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000358520200014 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276717]  |
| 专题 | 药物化学研究室 药物安全性评价中心 |
| 通讯作者 | Wu, Xiaowei |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Xiaowei,Zhang, Dengyou,Zhou, Shengbin,et al. Site-specific indolation of proline-based peptides via copper(II)-catalyzed oxidative coupling of tertiary amine N-oxides[J]. CHEMICAL COMMUNICATIONS,2015,51(63):12571-12573. |
| APA | Wu, Xiaowei,Zhang, Dengyou,Zhou, Shengbin,Gao, Feng,&Liu, Hong.(2015).Site-specific indolation of proline-based peptides via copper(II)-catalyzed oxidative coupling of tertiary amine N-oxides.CHEMICAL COMMUNICATIONS,51(63),12571-12573. |
| MLA | Wu, Xiaowei,et al."Site-specific indolation of proline-based peptides via copper(II)-catalyzed oxidative coupling of tertiary amine N-oxides".CHEMICAL COMMUNICATIONS 51.63(2015):12571-12573. |
入库方式： OAI收割
来源：上海药物研究所
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