Computational Drug Repositioning for Cancer Therapeutics
文献类型：期刊论文
| 作者 | Jiao, Mingkun; Liu, Gang; Xue, Yu; Ding, Chunyong
|
| 刊名 | CURRENT TOPICS IN MEDICINAL CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 15期号:8页码:767-775 |
| 关键词 | Anticancer drugs Cancer therapeutics Computational drug repositioning Drug discovery Drug repositioning Drug repurposing |
| ISSN号 | 1568-0266 |
| DOI | 10.2174/1568026615666150302105831 |
| 文献子类 | Review |
| 英文摘要 | Due to ever-increasing failure rates, high cost, unsatisfactory safety profile, and limited efficacy associated with anticancer drug development, the repositioning of established non-cancer drugs for new oncology indications has emerged as an increasingly attractive approach to addressing the unmet cancer-related medical need. With the rapid development of bioinformatics, chemoinformatics as well as high-performance computing, drug repositioning is becoming more intentional than ever, and a significant surge of computational approaches has been well established to greatly facilitate drug repositioning for cancer treatment. In this review, we provide a brief overview of recent advances in the computational drug repositioning for anticancer applications with a specific emphasis on repositioning of non-cancer drugs by use of various computational approaches. |
| WOS关键词 | CHRONIC MYELOID-LEUKEMIA ; KINASE DOMAIN MUTATIONS ; TRANSCRIPTION 3 STAT3 ; SIGNAL TRANSDUCER ; ANTICANCER AGENTS ; MOLECULAR TARGETS ; OLD DRUGS ; IN-VITRO ; DISCOVERY ; INHIBITORS |
| 资助项目 | Chinese National Science Foundation[81402790] ; Shanghai Commission of Science and Technology[14PJ1410700] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000351854400006 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276740]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Ding, Chunyong |
| 作者单位 | 1.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, SIMM, Synthet Organ & Med Chem Lab, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiao, Mingkun,Liu, Gang,Xue, Yu,et al. Computational Drug Repositioning for Cancer Therapeutics[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY,2015,15(8):767-775. |
| APA | Jiao, Mingkun,Liu, Gang,Xue, Yu,&Ding, Chunyong.(2015).Computational Drug Repositioning for Cancer Therapeutics.CURRENT TOPICS IN MEDICINAL CHEMISTRY,15(8),767-775. |
| MLA | Jiao, Mingkun,et al."Computational Drug Repositioning for Cancer Therapeutics".CURRENT TOPICS IN MEDICINAL CHEMISTRY 15.8(2015):767-775. |
入库方式： OAI收割
来源：上海药物研究所
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