N-(1-Oxy-2-picolyl)oxalamic acids as a new type of O,O-ligands for the Cu-catalyzed N-arylation of azoles with aryl halides in water or organic solvent
文献类型：期刊论文
| 作者 | Wang, Yongbin1; Zhang, Yu3; Yang, Beibei1; Zhang, Ao2 ; Yao, Qizheng1
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 13期号:13页码:4101-4114 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c5ob00045a |
| 文献子类 | Article |
| 英文摘要 | N-(1-Oxy-pyridin-2-ylmethyl) oxalamic acids (L3-L5) were identified as novel efficient ligands for copper-catalyzed C-N cross-coupling of azoles and aryl halides in water. The N-arylation of imidazoles, indoles and pyrazoles proceeded with moderate to excellent yields and complete selectivity over aromatic amines and phenols. Moreover, L5, which is also efficient in organic solvent with low catalyst loading, can be used to promote the N-arylation reactions with water-sensitive materials. The catalytic mechanism was proposed based on the results of several verification experiments which indicated that the ligands as new-type chelators may coordinate to Cu(I) with two oxygen atoms of N-oxide and amide in the coupling process. |
| WOS关键词 | BOND-FORMING REACTIONS ; NITROGEN-CONTAINING HETEROCYCLES ; COUPLING REACTIONS ; COPPER(I) COMPLEXES ; ARYLBORONIC ACIDS ; HIGHLY EFFICIENT ; ULLMANN REACTION ; MILD CONDITIONS ; IONIC LIQUIDS ; O-ARYLATION |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000351597700030 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276743]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Zhang, Ao |
| 作者单位 | 1.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200000, Peoples R China 3.Allist Pharmaceut Inc, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Yongbin,Zhang, Yu,Yang, Beibei,et al. N-(1-Oxy-2-picolyl)oxalamic acids as a new type of O,O-ligands for the Cu-catalyzed N-arylation of azoles with aryl halides in water or organic solvent[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2015,13(13):4101-4114. |
| APA | Wang, Yongbin,Zhang, Yu,Yang, Beibei,Zhang, Ao,&Yao, Qizheng.(2015).N-(1-Oxy-2-picolyl)oxalamic acids as a new type of O,O-ligands for the Cu-catalyzed N-arylation of azoles with aryl halides in water or organic solvent.ORGANIC & BIOMOLECULAR CHEMISTRY,13(13),4101-4114. |
| MLA | Wang, Yongbin,et al."N-(1-Oxy-2-picolyl)oxalamic acids as a new type of O,O-ligands for the Cu-catalyzed N-arylation of azoles with aryl halides in water or organic solvent".ORGANIC & BIOMOLECULAR CHEMISTRY 13.13(2015):4101-4114. |
入库方式： OAI收割
来源：上海药物研究所
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