Asymmetric synthesis of alpha-(1-oxoisoindolin-3-yl)glycine: synthetic and mechanistic challenges
文献类型：期刊论文
| 作者 | Li, Tingting3,4; Zhou, Shengbin3; Wang, Jiang3 ; Luis Acena, Jose1; Soloshonok, Vadim A.1,2; Liu, Hong3,4
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| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2015 |
| 卷号 | 51期号:9页码:1624-1626 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/c4cc05659k |
| 文献子类 | Article |
| 英文摘要 | We report herein that the NaOMe-catalyzed reactions between the chiral glycine Schiff base (S)-4 with 2-cyanobenzaldehyde 3a provide for a convenient preparation of the novel alpha-(1-oxoisoindolin-3-yl) glycine 1 of high pharmaceutical potential. The reactions involve at least eight synthetic steps and can mechanistically be realized only with application of Ni(II) complexes described in this study. |
| WOS关键词 | ALPHA-AMINO-ACIDS ; MICHAEL ADDITION-REACTIONS ; NUCLEOPHILIC GLYCINE EQUIVALENTS ; VIRTUALLY COMPLETE CONTROL ; NI(II) COMPLEXES ; FACE DIASTEREOSELECTIVITY ; SCHIFF-BASES ; CHIRAL EQUIVALENTS ; DERIVATIVES ; EFFICIENT |
| 资助项目 | National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81025017] ; National S&T Major Projects[2012ZX09103101-072] ; National S&T Major Projects[2012ZX09301001-005] ; National S&T Major Projects[2013ZX09507-001] ; National S&T Major Projects[2014ZX09507002001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000348200100016 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276767]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Li, Tingting |
| 作者单位 | 1.Univ Basque Country, UPV EHU, Fac Chem, Dept Organ Chem 1, San Sebastian 20018, Spain; 2.Ikerbasque, Basque Fdn Sci, Bilbao 48013, Spain 3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China; 4.China Pharmaceut Univ Jiangsu, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Tingting,Zhou, Shengbin,Wang, Jiang,et al. Asymmetric synthesis of alpha-(1-oxoisoindolin-3-yl)glycine: synthetic and mechanistic challenges[J]. CHEMICAL COMMUNICATIONS,2015,51(9):1624-1626. |
| APA | Li, Tingting,Zhou, Shengbin,Wang, Jiang,Luis Acena, Jose,Soloshonok, Vadim A.,&Liu, Hong.(2015).Asymmetric synthesis of alpha-(1-oxoisoindolin-3-yl)glycine: synthetic and mechanistic challenges.CHEMICAL COMMUNICATIONS,51(9),1624-1626. |
| MLA | Li, Tingting,et al."Asymmetric synthesis of alpha-(1-oxoisoindolin-3-yl)glycine: synthetic and mechanistic challenges".CHEMICAL COMMUNICATIONS 51.9(2015):1624-1626. |
入库方式： OAI收割
来源：上海药物研究所
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