Late-stage diversification of biologically active pyridazinones via a direct C-H functionalization strategy
文献类型：期刊论文
| 作者 | Li, Wei1; Fan, Zhoulong2,3; Geng, Kaijun2,3; Xu, Youjun1; Zhang, Ao2,3
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 13期号:2页码:539-548 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c4ob02061h |
| 文献子类 | Article |
| 英文摘要 | Divergent C-H functionalization reactions (arylation, carboxylation, olefination, thiolation, acetoxylation, halogenation, naphthylation) using a pyridazinone moiety as an internal directing group were successfully established. This approach offers a late-stage, ortho-selective diversification of a biologically active pyridazinone scaffold. Seven series of novel pyridazinone analogues were synthesized conveniently as the synthetic precursors of potential sortase A (SrtA) inhibitors. |
| WOS关键词 | STAPHYLOCOCCUS-AUREUS SORTASE ; CATALYZED DIRECT ARYLATION ; BOND ACTIVATION ; MULTIKILOGRAM SYNTHESIS ; ANTIINFECTIVE THERAPY ; DIARYLIODONIUM SALTS ; COUPLING REACTIONS ; SODIUM PERSULFATE ; INTERNAL ALKYNES ; MILD CONDITIONS |
| 资助项目 | Chinese NSF[81125021] ; Chinese NSF[81373277] ; Chinese NSF[81430080] ; National Science & Technology Major Project on 'Key New Drug Creation and Manufacturing Program', China[2012ZX09103-101-035] ; National Science & Technology Major Project on 'Key New Drug Creation and Manufacturing Program', China[2012ZX09301001-007] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000346048600026 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276789]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Xu, Youjun |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China; 2.Chinese Acad Sci, SIMM, SOMCL, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Wei,Fan, Zhoulong,Geng, Kaijun,et al. Late-stage diversification of biologically active pyridazinones via a direct C-H functionalization strategy[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2015,13(2):539-548. |
| APA | Li, Wei,Fan, Zhoulong,Geng, Kaijun,Xu, Youjun,&Zhang, Ao.(2015).Late-stage diversification of biologically active pyridazinones via a direct C-H functionalization strategy.ORGANIC & BIOMOLECULAR CHEMISTRY,13(2),539-548. |
| MLA | Li, Wei,et al."Late-stage diversification of biologically active pyridazinones via a direct C-H functionalization strategy".ORGANIC & BIOMOLECULAR CHEMISTRY 13.2(2015):539-548. |
入库方式： OAI收割
来源：上海药物研究所
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