Rhodium(III)- and Iridium(III)-Catalyzed C7 Alkylation of Indolines with Diazo Compounds
文献类型：期刊论文
| 作者 | Ai, Wen1,2,3; Yang, Xueyan1,3; Wu, Yunxiang2; Wang, Xuan2; Li, Yuanchao2; Yang, Yaxi2 ; Zhou, Bing2
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| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2014-12-22 |
| 卷号 | 20期号:52页码:17653-17657 |
| 关键词 | alkylation C-H activation indolines iridium rhodium |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.201405077 |
| 文献子类 | Article |
| 英文摘要 | A Rh-III-catalyzed procedure for the C7-selective C-H alkylation of various indolines with alpha-diazo compounds at room temperature is reported. The advantages of this process are: 1) simple, mild, and pH-neutral reaction conditions, 2) broad substrate scope, 3) complete regioselectivity, 4) no need for an external oxidant, and 5) N-2 as the sole by-product. Furthermore, alkylation and bis-alkylation of carbazoles at the C1 and C8 positions have also been developed. More significantly, for the first time, a successful Ir-III-catalyzed intermolecular insertion of arene C-H bonds into a-diazo compounds is reported. |
| WOS关键词 | H BOND ACTIVATION ; NONREARRANGED MONOTERPENOID UNIT ; ROOM-TEMPERATURE ; CARBENOID FUNCTIONALIZATION ; METAL CARBENE ; INDOLES ; ARYLATION ; ALKENES ; ALKYNES ; ARENES |
| 资助项目 | National Natural Science Foundation of China[21302200] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000346468000046 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276795]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Yang, Yaxi |
| 作者单位 | 1.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China; 3.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ai, Wen,Yang, Xueyan,Wu, Yunxiang,et al. Rhodium(III)- and Iridium(III)-Catalyzed C7 Alkylation of Indolines with Diazo Compounds[J]. CHEMISTRY-A EUROPEAN JOURNAL,2014,20(52):17653-17657. |
| APA | Ai, Wen.,Yang, Xueyan.,Wu, Yunxiang.,Wang, Xuan.,Li, Yuanchao.,...&Zhou, Bing.(2014).Rhodium(III)- and Iridium(III)-Catalyzed C7 Alkylation of Indolines with Diazo Compounds.CHEMISTRY-A EUROPEAN JOURNAL,20(52),17653-17657. |
| MLA | Ai, Wen,et al."Rhodium(III)- and Iridium(III)-Catalyzed C7 Alkylation of Indolines with Diazo Compounds".CHEMISTRY-A EUROPEAN JOURNAL 20.52(2014):17653-17657. |
入库方式： OAI收割
来源：上海药物研究所
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