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Recent advances in the trifluoromethylation methodology and new CF3-containing drugs
文献类型：期刊论文
| 作者 | Zhu, Wei2; Wang, Jiang2 ; Wang, Shuni2; Gu, Zhanni2; Luis Acena, Jose3; Izawa, Kunisuke4; Liu, Hong2; Soloshonok, Vadim A.1,3
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| 刊名 | JOURNAL OF FLUORINE CHEMISTRY
 |
| 出版日期 | 2014-11 |
| 卷号 | 167页码:37-54 |
| 关键词 | Trifluoromethylation Methodology Fluorine-containing drugs Pharmaceuticals Biological activity |
| ISSN号 | 0022-1139 |
| DOI | 10.1016/j.jfluchem.2014.06.026 |
| 文献子类 | Article |
| 英文摘要 | This review provides a brief assessment of the methodological field of trifluoromethylation and its possible impact on the development of new CF3-containing pharmaceuticals. Structural aspects of five new drug-candidates, [tafenoquine (aromatic CF3), roniciclib (heteroaromatic CF3), BAY-38-7271 (aliphatic CF3), sonidegib (O-CF3) and navitoclax (S-CF3)] currently under the development in phase II and III clinical studies, and their biological properties, therapeutic area and synthesis are critically discussed. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS关键词 | COPPER-CATALYZED TRIFLUOROMETHYLATION ; CANNABINOID RECEPTOR AGONIST ; BETA-AMINO ACIDS ; SILVER-MEDIATED TRIFLUOROMETHYLATION ; LIGHT PHOTOREDOX CATALYSIS ; ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION ; PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION ; IMMUNODEFICIENCY-VIRUS TYPE-1 ; ACHIRAL-PHASE CHROMATOGRAPHY ; HYPERVALENT IODINE REAGENT |
| 资助项目 | Ikerbasque[00000000] ; Basque Foundation for Science[00000000] ; Basque Government[SAIOTEK S-PE13UN098] ; National Natural Science Foundation of China[81025017] ; Hamari Chemicals (Osaka, Japan)[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000345469400005 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276847]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Basque Fdn Sci, Ikerbasque, Bilbao 48011, Spain 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 3.Univ Basque Country, Fac Chem, UPV EHU, Dept Quim Chem 1, San Sebastian 20018, Spain; 4.Hamari Chem Ltd, Higashi Yodogawa Ku, Osaka 5330024, Japan; |
| 推荐引用方式 GB/T 7714 | Zhu, Wei,Wang, Jiang,Wang, Shuni,et al. Recent advances in the trifluoromethylation methodology and new CF3-containing drugs[J]. JOURNAL OF FLUORINE CHEMISTRY,2014,167:37-54. |
| APA | Zhu, Wei.,Wang, Jiang.,Wang, Shuni.,Gu, Zhanni.,Luis Acena, Jose.,...&Soloshonok, Vadim A..(2014).Recent advances in the trifluoromethylation methodology and new CF3-containing drugs.JOURNAL OF FLUORINE CHEMISTRY,167,37-54. |
| MLA | Zhu, Wei,et al."Recent advances in the trifluoromethylation methodology and new CF3-containing drugs".JOURNAL OF FLUORINE CHEMISTRY 167(2014):37-54. |
入库方式： OAI收割
来源：上海药物研究所
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