A glucan isolated from flowers of Lonicera japonica Thunb. inhibits aggregation and neurotoxicity of A beta(42)
文献类型：期刊论文
| 作者 | Wang, Peipei1,3 ; Liao, Wenfeng1; Fang, Jianping1; Liu, Qin1; Yao, Jian1; Hu, Minghua2; Ding, Kan1
|
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2014-09-22 |
| 卷号 | 110页码:142-147 |
| 关键词 | Lonicera japonica Thunb. A beta(42) Glucan Aggregation and neurotoxicity Alzheimer's disease |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2014.03.060 |
| 文献子类 | Article |
| 英文摘要 | Inhibition of A beta aggregation and attenuation of its cytotoxicity are considered to valuable therapeutics for Alzheimer's disease (AD). Here, a glucan named as LJW0F2 was purified from flowers of Lonicera japonica Thunb. Using monosaccharides composition analysis, methylation analysis, IR and NMR spectroscopy, this polysaccharide was elucidated to be an alpha-D-(1 -> 4)-glucan with an alpha-(1 -> 4) linked branch attached to the C-6 position. Its inhibitory effect on A beta(42) aggregation was measured by fluorescence spectroscopic analysis with thioflavine T (ThT) and atomic force microscopy (AFM). We showed that polysaccharide LJW0F2 could inhibit A beta(42) aggregation in a dose-dependent-manner. Besides, LJW0F2 could attenuate the cytotoxicity induced by A beta(42) aggregation in SH-SY5Y neuroblastoma cells. To the best of our knowledge, this was the first report that the exogenous plant-derived polysaccharide might block A beta(42) aggregation directly and reduce its toxicity in SH-SY5Y cells. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | AMYLOID-BETA-PROTEIN ; ALZHEIMERS-DISEASE ; TAU-PHOSPHORYLATION ; OLIGOMERS ; POLYSACCHARIDE ; TOXICITY ; NEURONS ; CHAIN |
| 资助项目 | New Drug Creation and Manufacturing Program[2012ZX09301001-003] ; National Science Fund[81125025] ; National Natural Science Foundation of China[31230022] ; Industry-University-Research Institute Alliance Fund in Guangdong Province, China[2010A090200041] ; Shanghai Research Program[13ZR1447500] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000338005000020 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276896]  |
| 专题 | 药理学第三研究室 国家新药筛选中心 |
| 通讯作者 | Ding, Kan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China; 2.Infinitus Co Ltd, Guangzhou 510623, Guangdong, Peoples R China; 3.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Peipei,Liao, Wenfeng,Fang, Jianping,et al. A glucan isolated from flowers of Lonicera japonica Thunb. inhibits aggregation and neurotoxicity of A beta(42)[J]. CARBOHYDRATE POLYMERS,2014,110:142-147. |
| APA | Wang, Peipei.,Liao, Wenfeng.,Fang, Jianping.,Liu, Qin.,Yao, Jian.,...&Ding, Kan.(2014).A glucan isolated from flowers of Lonicera japonica Thunb. inhibits aggregation and neurotoxicity of A beta(42).CARBOHYDRATE POLYMERS,110,142-147. |
| MLA | Wang, Peipei,et al."A glucan isolated from flowers of Lonicera japonica Thunb. inhibits aggregation and neurotoxicity of A beta(42)".CARBOHYDRATE POLYMERS 110(2014):142-147. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。