Novel approaches to drug discovery for the treatment of type 2 diabetes
文献类型：期刊论文
| 作者 | Xu, Xing; Wang, Gaihong; Zhou, Tingting; Chen, Lili ; Chen, Jing; Shen, Xu
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| 刊名 | EXPERT OPINION ON DRUG DISCOVERY
 |
| 出版日期 | 2014-09 |
| 卷号 | 9期号:9页码:1047-1058 |
| 关键词 | beta-cell mass autophagy endoplasmic reticulum stress insulin secretion oxidative stress type 2 diabetes |
| ISSN号 | 1746-0441 |
| DOI | 10.1517/17460441.2014.941352 |
| 文献子类 | Review |
| 英文摘要 | Introduction: Type 2 diabetes mellitus (T2DM) is a chronic, complex and multifactorial metabolic disorder, which has become a serious global health problem. The side effects of known drugs and the deficiency of long-term safety data, in addition to the already determined adverse effects for the current preclinical drugs against T2DM, have largely called upon the urgent exploration of novel therapeutic and preventative strategies against this disease. Areas covered: The authors highlight the potential approaches for anti-T2DM drug discovery by focusing on: the restoration of pancreatic beta-cell mass, the promotion of insulin secretion, the regulation of oxidative stress and endoplasmic reticulum (ER) stress and the modulation of autophagy. Expert opinion: T2DM is based on the gradual development of insulin resistance and beta-cell dysfunction. Thus, the restoration of beta-cell function is considered as one of the promising therapeutic strategies against T2DM. The stress factors, such as oxidative stress, ER stress and autophagy, play potent roles in the regulation of beta-cell apoptosis, insulin secretion and sensitivity in the development of T2DM involving complicated cross-talks. Based on multiplex stress-involved regulatory networks, more and more novel potential targets have been discovered and the multi-targeted drug leads are expected to help develop more effective clinical agents for the treatment of T2DM. |
| WOS关键词 | PANCREATIC BETA-CELLS ; ENDOPLASMIC-RETICULUM STRESS ; STIMULATED INSULIN-SECRETION ; GENOME-WIDE ASSOCIATION ; OXIDATIVE STRESS ; HUMAN ISLETS ; MITOCHONDRIAL DYSFUNCTION ; MOLECULAR-MECHANISMS ; METABOLIC DISEASE ; PROTEIN-KINASE |
| 资助项目 | National Natural Science Foundation of China[81220108025] ; National Natural Science Foundation of China[81373462] ; National Natural Science Foundation of China[81373461] ; Science Foundation of Shanghai[12431900300] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000340828500007 |
| 出版者 | INFORMA HEALTHCARE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276929]  |
| 专题 | 生物技术药物研发中心（筹） 药理学第三研究室 药物安全性评价中心 |
| 通讯作者 | Chen, Lili |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Xing,Wang, Gaihong,Zhou, Tingting,et al. Novel approaches to drug discovery for the treatment of type 2 diabetes[J]. EXPERT OPINION ON DRUG DISCOVERY,2014,9(9):1047-1058. |
| APA | Xu, Xing,Wang, Gaihong,Zhou, Tingting,Chen, Lili,Chen, Jing,&Shen, Xu.(2014).Novel approaches to drug discovery for the treatment of type 2 diabetes.EXPERT OPINION ON DRUG DISCOVERY,9(9),1047-1058. |
| MLA | Xu, Xing,et al."Novel approaches to drug discovery for the treatment of type 2 diabetes".EXPERT OPINION ON DRUG DISCOVERY 9.9(2014):1047-1058. |
入库方式： OAI收割
来源：上海药物研究所
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