Structure and biological activities of an alginate from Sargassum fusiforme, and its sulfated derivative
文献类型：期刊论文
| 作者 | Cong, Qifei; Xiao, Fei; Liao, Wenfeng; Dong, Qun; Ding, Kan
|
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2014-08 |
| 卷号 | 69页码:252-259 |
| 关键词 | Sargassum fusiforme Alginate Anti-angiogenic activity |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2014.05.056 |
| 文献子类 | Article |
| 英文摘要 | An alginate fraction, 04S2P, was isolated from the brown seaweed Sargassum fusiforme and was structurally characterized by the ratio (M/G) of beta-D-mannuronic acid residues (M) to alpha-L-guluronic acid residues (G) via H-1 and C-13 NMR spectroscopy. When compared to commercial alginate (Alg) and alginates from other brown algae, 04S2P has a higher M/G ratio of 9.0:1.0 as determined by a modified high-performance liquid chromatography method after pre-column derivatization with PMP. Furthermore, the sulfated polysaccharides 04S2P-S and Alg-S were prepared by the chlorosulfonic acid-pyridine method. Both C-2 and/or C-3 of M and G residues of 04S2P-S were substituted by sulfate groups, with C-3 of M residues preferentially substituted. Their effects on tube formation of HMEC-1 cells were examined, and the results indicated that the sulfated Alg, Alg-S, exhibited a strong anti-angiogenic effect on HMEC-1 cells. The anti-tumor activity of native and sulfated alginates was tested on five different tumor cell lines. Alg-S demonstrated significant anti-tumor effects on the Bel7402, SMMC7721, and HT-29 cell lines, whereas 04S2P-S showed a distinct anti-tumor effect only on the Bel7402 cell line. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS关键词 | ANTICOAGULANT ACTIVITIES ; CYTOKINE PRODUCTION ; OLIGOSACCHARIDES ; SPECTROSCOPY ; INDUCTION ; RELEASE ; BINDING ; ALGA |
| 资助项目 | National Natural Science Foundation of China (NSFC)[81171914] ; National Natural Science Foundation of China (NSFC)[31230022] ; New Drug Creation and Manufacturing Program[2012ZX09301001-003] ; National Science Fund for Distinguished Young Scholars in China[81125025] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000340323100036 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276963]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Dong, Qun |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cong, Qifei,Xiao, Fei,Liao, Wenfeng,et al. Structure and biological activities of an alginate from Sargassum fusiforme, and its sulfated derivative[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2014,69:252-259. |
| APA | Cong, Qifei,Xiao, Fei,Liao, Wenfeng,Dong, Qun,&Ding, Kan.(2014).Structure and biological activities of an alginate from Sargassum fusiforme, and its sulfated derivative.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,69,252-259. |
| MLA | Cong, Qifei,et al."Structure and biological activities of an alginate from Sargassum fusiforme, and its sulfated derivative".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 69(2014):252-259. |
入库方式： OAI收割
来源：上海药物研究所
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