Structure and activities of a novel heteroxylan from Cassia obtusifolia seeds and its sulfated derivative
文献类型：期刊论文
| 作者 | Cong, Qifei; Shang, Mingsheng; Dong, Qun; Liao, Wenfeng; Xiao, Fei; Ding, Kan
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| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2014-07-01 |
| 卷号 | 393页码:43-50 |
| 关键词 | Cassia obtusifolia Structure Glucuronoxylan Anti-angiogenesis Anti-tumor |
| ISSN号 | 0008-6215 |
| DOI | 10.1016/j.carres.2014.04.016 |
| 文献子类 | Article |
| 英文摘要 | COB1B1S2 was isolated from an alkaline extract of Cassia obtusifolia seeds, and purified by anion-exchange and gel permeation chromatography. It contains arabinose, xylose, and glucuronic acid, in the molar ratio of 5: 81: 14, with an apparent molecular weight estimated to be 70.4 kDa. Elucidated by using chemical and spectroscopic methods, COB1B1S2 was shown to have a backbone consisting of 1,4-linked-D-Xylp, with one single-unit terminal alpha-D-GlcpA or alpha-L-Araf substituted at O-2 for nearly every five 1,4-linked Xylp. COB1B1S2 is structurally different from typical glucuronoxylans by its absence of methylation at O-4 of GlcA. The native COB1B1S2 showed no significant inhibition on the tube formation of human microvascular endothelial cells (HMEC) and on the growth of liver and colon cancer cells. On the contrary, COB1B1S2-Sul, prepared as the sulfated derivative of COB1B1S2, exhibited a significant inhibition on tube formation of HMEC in a dose-dependent manner, and on the growth of Bel7402 liver cancer cells. These results indicated that the introduction of sulfate groups significantly enhanced the biological activity of glucuronoxylan. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | NMR CHARACTERIZATION ; POLYSACCHARIDES ; HEMICELLULOSES ; XYLANS |
| 资助项目 | National Natural Science Foundation of China (NSFC)[81171914] ; National Natural Science Foundation of China (NSFC)[31230022] ; New Drug Creation and Manufacturing Program[2012ZX09301001-003] ; National Science Fund for Distinguished Young Scholars in China[81125025] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000338714300008 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277005]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Dong, Qun |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cong, Qifei,Shang, Mingsheng,Dong, Qun,et al. Structure and activities of a novel heteroxylan from Cassia obtusifolia seeds and its sulfated derivative[J]. CARBOHYDRATE RESEARCH,2014,393:43-50. |
| APA | Cong, Qifei,Shang, Mingsheng,Dong, Qun,Liao, Wenfeng,Xiao, Fei,&Ding, Kan.(2014).Structure and activities of a novel heteroxylan from Cassia obtusifolia seeds and its sulfated derivative.CARBOHYDRATE RESEARCH,393,43-50. |
| MLA | Cong, Qifei,et al."Structure and activities of a novel heteroxylan from Cassia obtusifolia seeds and its sulfated derivative".CARBOHYDRATE RESEARCH 393(2014):43-50. |
入库方式： OAI收割
来源：上海药物研究所
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