Naphthoquinone-Directed C-H Annulation and C-sp3-H Bond Cleavage: One-Pot Synthesis of Tetracyclic Naphthoxazoles
文献类型：期刊论文
| 作者 | Wang, Meining1,2; Zhang, Chi3; Sun, Li-Ping3; Ding, Chunyong1,2 ; Zhang, Ao1,2
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2014-05-16 |
| 卷号 | 79期号:10页码:4553-4560 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/jo500572u |
| 文献子类 | Article |
| 英文摘要 | One-pot synthesis of tetracyclic naphthoxazole derivatives from electron-deficient naphthoquinones and alkynes was achieved via Rh(III)-catalyzed C-H activation and C-sp3-H bond cleavage for the first time. This approach proceeds through a tandem cascade process involving substrate tautomerization, C-H activation, oxidative addition, cyclization, and aromatization. In addition, broad substrate scope, simple starting materials, and steric tolerance make this strategy of great practicality. |
| WOS关键词 | INTERNAL ALKYNES ; OXIDATIVE ANNULATION ; PSEUDOPTEROGORGIA-ELISABETHAE ; RHODIUM CATALYSIS ; DNA-BINDING ; ACTIVATION ; BENZOXAZOLES ; FUNCTIONALIZATION ; DERIVATIVES ; COUPLING/CYCLIZATION |
| 资助项目 | Chinese National Sciences Foundation[81125021] ; Chinese National Sciences Foundation[81373277] ; National Science & Technology Major Project on "Key New Drug Creation and Manufacturing Program", China[2012ZX09103-101-035] ; National Science & Technology Major Project on "Key New Drug Creation and Manufacturing Program", China[2012ZX09301001-001] ; "Interdisciplinary Cooperation Team" Program for Science and Technology Innovation (CAS)[00000000] ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica[SIMM1302KF-08] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000336199800034 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277073]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Zhang, Ao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, SOMCL, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 3.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Meining,Zhang, Chi,Sun, Li-Ping,et al. Naphthoquinone-Directed C-H Annulation and C-sp3-H Bond Cleavage: One-Pot Synthesis of Tetracyclic Naphthoxazoles[J]. JOURNAL OF ORGANIC CHEMISTRY,2014,79(10):4553-4560. |
| APA | Wang, Meining,Zhang, Chi,Sun, Li-Ping,Ding, Chunyong,&Zhang, Ao.(2014).Naphthoquinone-Directed C-H Annulation and C-sp3-H Bond Cleavage: One-Pot Synthesis of Tetracyclic Naphthoxazoles.JOURNAL OF ORGANIC CHEMISTRY,79(10),4553-4560. |
| MLA | Wang, Meining,et al."Naphthoquinone-Directed C-H Annulation and C-sp3-H Bond Cleavage: One-Pot Synthesis of Tetracyclic Naphthoxazoles".JOURNAL OF ORGANIC CHEMISTRY 79.10(2014):4553-4560. |
入库方式： OAI收割
来源：上海药物研究所
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