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Synthesis and biological evaluation of 20-hydroxytriptonide and its analogues

文献类型：期刊论文

作者Xu, Hongtao2; Tang, Huanyu2; Yang, Zhuo1; Feng, Huijin2; Li, Yuanchao2
刊名TETRAHEDRON
出版日期2014-05-13
卷号70期号:19页码:3107-3115
关键词Diterpenoid Triptolide Triptonide Cytotoxic Synthesis
ISSN号0040-4020
DOI10.1016/j.tet2014.03.070
文献子类Article
英文摘要20-Hydroxytriptonide was synthesized from readily accessible L-abietic acid in 22 linear steps, which features a Barton reaction carried out under air atmosphere to install the C20-hydroxy group. Meanwhile, we also synthesized (5R)-5-hydroxytriptolide's probable metabolite product. Preliminary structure activity relationship studies revealed that C20-angular methyl group might play a key role in maintaining the electronic properties of the whole molecule, which was essential for retaining the cytotoxic activity and might easily and inevitably be affected by the introduction of a new group. (C) 2014 Elsevier Ltd. All rights reserved.
WOS关键词INTRAMOLECULAR HYDROGEN ABSTRACTION ; TRIPTERYGIUM-WILFORDII ; CLINICAL-TRIALS ; TRIPTOLIDE ; (-)-TRIPTOLIDE ; ALPHA ; CELLS ; ALDOSTERONE ; TRIPTONIDE ; ALCOHOLS
资助项目Shanghai Science and Technology Commission, China[13431900403] ; National Natural Science Foundation of NFSC, China[81373479]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000335274600002
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/277077]  
专题药物化学研究室
通讯作者Li, Yuanchao
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Xu, Hongtao,Tang, Huanyu,Yang, Zhuo,et al. Synthesis and biological evaluation of 20-hydroxytriptonide and its analogues[J]. TETRAHEDRON,2014,70(19):3107-3115.
APA Xu, Hongtao,Tang, Huanyu,Yang, Zhuo,Feng, Huijin,&Li, Yuanchao.(2014).Synthesis and biological evaluation of 20-hydroxytriptonide and its analogues.TETRAHEDRON,70(19),3107-3115.
MLA Xu, Hongtao,et al."Synthesis and biological evaluation of 20-hydroxytriptonide and its analogues".TETRAHEDRON 70.19(2014):3107-3115.

入库方式： OAI收割

来源：上海药物研究所

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