Synthesis and biological evaluation of 20-hydroxytriptonide and its analogues
文献类型:期刊论文
作者 | Xu, Hongtao2; Tang, Huanyu2; Yang, Zhuo1; Feng, Huijin2![]() |
刊名 | TETRAHEDRON
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出版日期 | 2014-05-13 |
卷号 | 70期号:19页码:3107-3115 |
关键词 | Diterpenoid Triptolide Triptonide Cytotoxic Synthesis |
ISSN号 | 0040-4020 |
DOI | 10.1016/j.tet2014.03.070 |
文献子类 | Article |
英文摘要 | 20-Hydroxytriptonide was synthesized from readily accessible L-abietic acid in 22 linear steps, which features a Barton reaction carried out under air atmosphere to install the C20-hydroxy group. Meanwhile, we also synthesized (5R)-5-hydroxytriptolide's probable metabolite product. Preliminary structure activity relationship studies revealed that C20-angular methyl group might play a key role in maintaining the electronic properties of the whole molecule, which was essential for retaining the cytotoxic activity and might easily and inevitably be affected by the introduction of a new group. (C) 2014 Elsevier Ltd. All rights reserved. |
WOS关键词 | INTRAMOLECULAR HYDROGEN ABSTRACTION ; TRIPTERYGIUM-WILFORDII ; CLINICAL-TRIALS ; TRIPTOLIDE ; (-)-TRIPTOLIDE ; ALPHA ; CELLS ; ALDOSTERONE ; TRIPTONIDE ; ALCOHOLS |
资助项目 | Shanghai Science and Technology Commission, China[13431900403] ; National Natural Science Foundation of NFSC, China[81373479] |
WOS研究方向 | Chemistry |
语种 | 英语 |
WOS记录号 | WOS:000335274600002 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
源URL | [http://119.78.100.183/handle/2S10ELR8/277077] ![]() |
专题 | 药物化学研究室 |
通讯作者 | Li, Yuanchao |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China; |
推荐引用方式 GB/T 7714 | Xu, Hongtao,Tang, Huanyu,Yang, Zhuo,et al. Synthesis and biological evaluation of 20-hydroxytriptonide and its analogues[J]. TETRAHEDRON,2014,70(19):3107-3115. |
APA | Xu, Hongtao,Tang, Huanyu,Yang, Zhuo,Feng, Huijin,&Li, Yuanchao.(2014).Synthesis and biological evaluation of 20-hydroxytriptonide and its analogues.TETRAHEDRON,70(19),3107-3115. |
MLA | Xu, Hongtao,et al."Synthesis and biological evaluation of 20-hydroxytriptonide and its analogues".TETRAHEDRON 70.19(2014):3107-3115. |
入库方式: OAI收割
来源:上海药物研究所
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