Synthesis of Pyrazolo[1,2-a] cinnolines via a Rhodium-Catalyzed Oxidative Coupling Approach
文献类型：期刊论文
| 作者 | Xing, Li2; Fan, Zhoulong1,3; Hou, Chengyu2; Yong, Guoping2; Zhang, Ao1,3
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| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
 |
| 出版日期 | 2014-03-24 |
| 卷号 | 356期号:5页码:972-976 |
| ISSN号 | 1615-4150 |
| 关键词 | alkynes oxidative coupling pyrazolo[1 2-a]cinnolines pyrazolones rhodium |
| DOI | 10.1002/adsc.201301009 |
| 文献子类 | Article |
| 英文摘要 | An efficient synthetic strategy for the unique class of pyrazolo[1,2-a]cinnolines was developed through a rhodium-catalyzed oxidative coupling of N-aryl-1H-pyrazol-5(4H)-ones with internal alkynes. This protocol features use of the pyrazolone function in the substrate as an intrinsic directing group, hexafluoroisopropyl alcohol (HFIP) as the solvent, and mild reaction conditions as well as a wide substrate scope. |
| WOS关键词 | C-H ACTIVATION ; N BOND FORMATION ; INTERNAL ALKYNES ; ANTIBACTERIAL ACTIVITY ; ANTICANCER AGENTS ; SALTS ; DERIVATIVES ; CYCLIZATION ; ANNULATION ; CLEAVAGE |
| 资助项目 | Chinese National Sciences Foundation[81125021] ; Chinese National Sciences Foundation[81373277] ; National Science & Technology Major Project on "Key New Drug Creation and Manufacturing Program, China[2012ZX09103-101-035] ; National Science & Technology Major Project on "Key New Drug Creation and Manufacturing Program, China[2012ZX09301001-001] ; "Interdisciplinary Cooperation Team" Program for Science and Technology Innovation (CAS)[00000000] ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica[SIMM1302KF-08] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000333196000009 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277151]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Zhang, Ao |
| 作者单位 | 1.Chinese Acad Sci, SOMCL, SIMM, Shanghai 201203, Peoples R China 2.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China; 3.Chinese Acad Sci, CAS Key Lab Receptor Res, SIMM, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xing, Li,Fan, Zhoulong,Hou, Chengyu,et al. Synthesis of Pyrazolo[1,2-a] cinnolines via a Rhodium-Catalyzed Oxidative Coupling Approach[J]. ADVANCED SYNTHESIS & CATALYSIS,2014,356(5):972-976. |
| APA | Xing, Li,Fan, Zhoulong,Hou, Chengyu,Yong, Guoping,&Zhang, Ao.(2014).Synthesis of Pyrazolo[1,2-a] cinnolines via a Rhodium-Catalyzed Oxidative Coupling Approach.ADVANCED SYNTHESIS & CATALYSIS,356(5),972-976. |
| MLA | Xing, Li,et al."Synthesis of Pyrazolo[1,2-a] cinnolines via a Rhodium-Catalyzed Oxidative Coupling Approach".ADVANCED SYNTHESIS & CATALYSIS 356.5(2014):972-976. |
入库方式： OAI收割
来源：上海药物研究所
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