Design, synthesis and anticancer activity evaluation of novel C14 heterocycle substituted epi-triptolide
文献类型：期刊论文
| 作者 | Xu, Hongtao; Tang, Huanyu; Feng, Huijin ; Li, Yuanchao
|
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2014-02-12 |
| 卷号 | 73页码:46-55 |
| 关键词 | Triptolide Heterocycle Synthesis Anticancer SKOV-3 PC-3 |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2013.11.044 |
| 文献子类 | Article |
| 英文摘要 | Two series of novel C14 heterocycle substituted epi-triptolide derivatives as potential anticancer agents were synthesized and tested for their cytotoxicity against SKOV-3 and PC-3 tumor cell lines. The introduction of C14 beta-aryl heterocycle aminomethyl substituent to the leading compound was found to be an effective modification method to retain the potent anticancer activity. Meanwhile, the series of epitriptolide derivatives (21-40) with C14 alpha-hydroxyl group, still retained the natural product's cytotoxicity. This is apparently challenges the classical structure activity relationship of triptolide that considers the C14 beta-hydroxyl group to be essential for its anticancer activity. (C) 2013 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | TRIPTERYGIUM-WILFORDII ; NATURAL-PRODUCTS ; CELL-DEATH ; APOPTOSIS ; PG490 ; CHEMOTHERAPY ; TRIPDIOLIDE ; ACTIVATION ; CHEMISTRY ; PATHWAY |
| 资助项目 | Shanghai Science and Technology Commission "biomedicine technology support project", China[13431900403] ; National Natural Science Foundation of NFSC, China[81373479] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000331916500006 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277186]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Li, Yuanchao |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Hongtao,Tang, Huanyu,Feng, Huijin,et al. Design, synthesis and anticancer activity evaluation of novel C14 heterocycle substituted epi-triptolide[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2014,73:46-55. |
| APA | Xu, Hongtao,Tang, Huanyu,Feng, Huijin,&Li, Yuanchao.(2014).Design, synthesis and anticancer activity evaluation of novel C14 heterocycle substituted epi-triptolide.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,73,46-55. |
| MLA | Xu, Hongtao,et al."Design, synthesis and anticancer activity evaluation of novel C14 heterocycle substituted epi-triptolide".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 73(2014):46-55. |
入库方式： OAI收割
来源：上海药物研究所
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